Journal article
Microvascular and tissue oxygen gradients in the rat mesentery
Proceedings of the National Academy of Sciences - PNAS, v 95(12), pp 6590-6595
09 Jun 1998
PMID: 9618456
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
One of the most important functions of the blood circulation is O
2
delivery to the tissue. This process occurs primarily in microvessels that also regulate blood flow and are the site of many metabolic processes that require O
2
. We measured the intraluminal and perivascular pO
2
in rat mesenteric arterioles
in vivo
by using noninvasive phosphorescence quenching microscopy. From these measurements, we calculated the rate at which O
2
diffuses out of microvessels from the blood. The rate of O
2
efflux and the O
2
gradients found in the immediate vicinity of arterioles indicate the presence of a large O
2
sink at the interface between blood and tissue, a region that includes smooth muscle and endothelium. Mass balance analyses show that the loss of O
2
from the arterioles in this vascular bed primarily is caused by O
2
consumption in the microvascular wall. The high metabolic rate of the vessel wall relative to parenchymal tissue in the rat mesentery suggests that in addition to serving as a conduit for the delivery of O
2
the microvasculature has other functions that require a significant amount of O
2
.
Metrics
Details
- Title
- Microvascular and tissue oxygen gradients in the rat mesentery
- Creators
- Amy G. Tsai - University of California SystemBarbara FrieseneckerMichelle C. MazzoniHeinz KergerDonald G. BuerkPaul C. JohnsonMarcos Intaglietta
- Publication Details
- Proceedings of the National Academy of Sciences - PNAS, v 95(12), pp 6590-6595
- Publisher
- The National Academy of Sciences
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000074131900006
- Scopus ID
- 2-s2.0-0032499677
- Other Identifier
- 991019231647704721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Peripheral Vascular Disease