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Journal article
Mining Temporal Protein Complex Based on the Dynamic PIN Weighted with Connected Affinity and Gene Co-Expression
PloS one, Vol.11(4), pp.e0153967-e0153967
2016
PMCID: PMC4839750
PMID: 27100396
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The identification of temporal protein complexes would make great contribution to our knowledge of the dynamic organization characteristics in protein interaction networks (PINs). Recent studies have focused on integrating gene expression data into static PIN to construct dynamic PIN which reveals the dynamic evolutionary procedure of protein interactions, but they fail in practice for recognizing the active time points of proteins with low or high expression levels. We construct a Time-Evolving PIN (TEPIN) with a novel method called Deviation Degree, which is designed to identify the active time points of proteins based on the deviation degree of their own expression values. Owing to the differences between protein interactions, moreover, we weight TEPIN with connected affinity and gene co-expression to quantify the degree of these interactions. To validate the efficiencies of our methods, ClusterONE, CAMSE and MCL algorithms are applied on the TEPIN, DPIN (a dynamic PIN constructed with state-of-the-art three-sigma method) and SPIN (the original static PIN) to detect temporal protein complexes. Each algorithm on our TEPIN outperforms that on other networks in terms of match degree, sensitivity, specificity, F-measure and function enrichment etc. In conclusion, our Deviation Degree method successfully eliminates the disadvantages which exist in the previous state-of-the-art dynamic PIN construction methods. Moreover, the biological nature of protein interactions can be well described in our weighted network. Weighted TEPIN is a useful approach for detecting temporal protein complexes and revealing the dynamic protein assembly process for cellular organization.
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Details
- Title
- Mining Temporal Protein Complex Based on the Dynamic PIN Weighted with Connected Affinity and Gene Co-Expression
- Creators
- Xianjun Shen - Central China Normal UniversityLi Yi - Central China Normal UniversityXingpeng Jiang - Central China Normal UniversityTingting He - Central China Normal UniversityXiaohua Hu - Central China Normal UniversityJincai Yang - Central China Normal University
- Publication Details
- PloS one, Vol.11(4), pp.e0153967-e0153967
- Publisher
- Public LIbrary of Science (PLOS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Information Science (Informatics)
- Identifiers
- 991019167544504721
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- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemical Research Methods