Journal article
Mining heterogeneous network for drug repositioning using phenotypic information extracted from social media and pharmaceutical databases
Artificial intelligence in medicine, v 96, pp 80-92
May 2019
PMID: 31164213
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Drug repositioning has drawn significant attention for drug development in pharmaceutical research and industry, because of its advantages in cost and time compared with the de novo drug development. The availability of biomedical databases and online health-related information, as well as the high-performance computing, empowers the development of computational drug repositioning methods. In this work, we developed a systematic approach that identifies repositioning drugs based on heterogeneous network mining using both pharmaceutical databases (PharmGKB and SIDER) and online health community (MedHelp). By utilizing adverse drug reactions (ADRs) as the intermediate, we constructed a heterogeneous health network containing drugs, diseases, and ADRs, and developed path-based heterogeneous network mining approaches for drug repositioning. Additionally, we investigated on how the data sources affect the performance on drug repositioning. Experiment results showed that combining both PharmKGB and MedHelp identified 479 repositioning drugs, which are more than the repositioning drugs discovered by other alternatives. In addition, 31% of the 479 of the discovered repositioning drugs were supported by evidence from PubMed.
Metrics
Details
- Title
- Mining heterogeneous network for drug repositioning using phenotypic information extracted from social media and pharmaceutical databases
- Creators
- Christopher C Yang - College of Computing and Informatics, Drexel University, Philadelphia, PA, United States. Electronic address: chris.yang@drexel.eduMengnan Zhao - College of Computing and Informatics, Drexel University, Philadelphia, PA, United States
- Publication Details
- Artificial intelligence in medicine, v 96, pp 80-92
- Publisher
- Elsevier; Netherlands
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Information Science
- Web of Science ID
- WOS:000472704800008
- Scopus ID
- 2-s2.0-85063750199
- Other Identifier
- 991014877861904721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Computer Science, Artificial Intelligence
- Engineering, Biomedical
- Medical Informatics