Journal article
Minireview: The Complexities of IGF/Insulin Signaling in Aging: Why Flies and Worms Are Not Humans
Molecular endocrinology (Baltimore, Md.), v 29(8), pp 1107-1113
01 Aug 2015
PMID: 26102060
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A remarkable plasticity in life span has been uncovered in recent years, offering hope that the basic mechanisms of aging and interventions that delay aging may be identified in the coming decades. Life span extension has been achieved by genetic manipulation in multiple organisms including Sarcomyces cervisae, Caenorhabditis elegans, and Drosophila melanogaster, resulting in more than a doubling of life span in some cases. Typically, a reduction in function has been the most effective approach to extending life span, and a reduction in the insulin/IGF-1 signaling pathway appears to provide the most robust increase in life span. This highly conserved pathway integrates growth/survival signals with nutrient status. In mammals, it comprises part of the neuroendocrine axis, a critical regulator of growth and development. Reduced functionality of the neuroendocrine axis itself promotes life span extension in mammals; however, reduced activity of the IGF-1 signaling pathway specifically leads to less robust increases in life span. This review examines the differences in the insulin/IGF-1 axis between invertebrate and mammalian systems and discusses implications of these differences in terms of life span modulation.
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Details
- Title
- Minireview: The Complexities of IGF/Insulin Signaling in Aging: Why Flies and Worms Are Not Humans
- Creators
- Christian Sell - Drexel University
- Publication Details
- Molecular endocrinology (Baltimore, Md.), v 29(8), pp 1107-1113
- Publisher
- Oxford Univ Press
- Number of pages
- 7
- Grant note
- AG039799 / National Institute on Aging, National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) R21AG039799 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000365271800003
- Scopus ID
- 2-s2.0-84938337950
- Other Identifier
- 991019168747104721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Endocrinology & Metabolism