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Journal article
Minor physical anomalies are not increased in the offspring of mothers with systemic lupus erythematosus
Annals of the rheumatic diseases, v 65(2), pp 246-248
01 Feb 2006
PMID: 15994279
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective: To determine the incidence and type of minor physical anomalies (MPAs) in infants born to mothers with systemic lupus erythematosus (SLE). Methods: Each trimester, pregnant women with SLE were assessed for disease activity, prescribed drug use, and exposure to tobacco, alcohol, and illicit drugs through a self reported questionnaire. Infant examinations were performed on 30/39 (77%) live births in women with SLE and the incidence of MPAs determined. Results: 2/30 (7%) patients had three or more MPAs; 4 (13%) had two; 7 (23%) had one; and 17 (57%) had none. One in three women reported alcohol, tobacco, and illicit drug use. Facial anomalies were the most common MPAs. The relative risk and 95% confidence interval for any MPA were 2.05 (0.99 to 4.26) for tobacco use; 1.95 (0.92 to 4.11) for alcohol use; 1.36 (0.165 to 11.23) for maternal disease flare; 0.63 (0.27 to 1.47) for prednisone use; and 0.72 (0.21 to 2.44) for aspirin use. Conclusion: 13/30 (43%) infants had minor anomalies—a similar incidence to that of the general population. Counselling for preventable self reported exposure is advisable in addition to counselling specifically for lupus management during pregnancy.
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Details
- Title
- Minor physical anomalies are not increased in the offspring of mothers with systemic lupus erythematosus
- Creators
- P N Bonaminio - Northwestern UniversityR de Regnier - Northwestern University/The Feinberg School of Medicine, Chicago IL 60611, USAE Chang - Northwestern UniversityN Day - University of PittsburghS Manzi - University of PittsburghR Ramsey-Goldman - Center for Rheumatology
- Publication Details
- Annals of the rheumatic diseases, v 65(2), pp 246-248
- Publisher
- BMJ Publishing Group Ltd and European League Against Rheumatism
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- General Internal Medicine
- Web of Science ID
- WOS:000234588900020
- Scopus ID
- 2-s2.0-31144444781
- Other Identifier
- 991021933902504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Rheumatology