Journal article
Missed congenital hypothyroidism in an identical twin
Journal of paediatrics and child health, v 48(10), pp 936-938
01 Oct 2012
PMID: 22970836
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Newborn screening for congenital hypothyroidism has been remarkably effective, although rare cases of false negative screening have been reported in same sex twins, presumptively due to fetal blood exchange. We report a case in which the diagnosis of congenital hypothyroidism due to thyroid ectopia in a monozygotic twin was delayed by 8 months, with a normal newborn screening TSH level of 11 mIU/L blood (normal < 15 mIU/L) at 2 days of life. This is the first such case since the national New Zealand newborn screening programme introduced screening for congenital hypothyroidism in 1981 (30 years ago). Repeating thyroid studies at 14 days of age in same-sex twins has been advocated to avoid delayed diagnosis, but given the low risk, may not be cost effective. It is important to maintain a high index of suspicion in same-sex twin pregnancies of potential congenital hypothyroidism.
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Details
- Title
- Missed congenital hypothyroidism in an identical twin
- Creators
- Anita Azam - Starship Children's HealthWayne Cutfield - University of AucklandFran Mouat - Starship Children's HealthPaul L. Hofman - University of AucklandCraig Jefferies - Starship Children's HealthDianne Webster - Auckland District Health BoardAlistair Jan Gunn - University of Auckland
- Publication Details
- Journal of paediatrics and child health, v 48(10), pp 936-938
- Publisher
- Wiley
- Number of pages
- 3
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000310473200023
- Scopus ID
- 2-s2.0-84867898658
- Other Identifier
- 991021448027004721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Pediatrics