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Journal article
Mitochondria-Mediated Anticancer Effects of Non-Thermal Atmospheric Plasma
PloS one, v 11(6), pp e0156818-e0156818
06 Jun 2016
PMID: 27270230
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Non-thermal atmospheric pressure plasma has attracted great interest due to its multiple potential biomedical applications with cancer treatment being among the most urgent. To realize the clinical potential of non-thermal plasma, the exact cellular and molecular mechanisms of plasma effects must be understood. This work aimed at studying the prostate cancer specific mechanisms of non-thermal plasma effects on energy metabolism as a central regulator of cell homeostasis and proliferation. It was found that cancer cells with higher metabolic rate initially are more resistant to plasma treated phosphate-buffered saline (PBS) since the respiratory and calcium sensitive signaling systems were not responsive to plasma exposure. However, dramatic decline of cancer oxidative phosphorylation developed over time resulted in significant progression of cell lethality. The normal prostate cells with low metabolic activity immediately responded to plasma treated PBS by suppression of respiratory functions and sustained elevation of cytosolic calcium. However, over time the normal cells start recovering their mitochondria functions, proliferate and restore the cell population. We found that the non-thermal plasma induced increase in intracellular ROS is of primarily non-mitochondrial origin. The discriminate non-thermal plasma effects hold a promise for clinical cancer intervention.
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Details
- Title
- Mitochondria-Mediated Anticancer Effects of Non-Thermal Atmospheric Plasma
- Creators
- Aigul Zhunussova - Al-Farabi Kazakh National UniversityElina A. Vitol - Drexel UniversityBoris Polyak - Drexel UniversitySultan Tuleukhanov - Al-Farabi Kazakh National UniversityAri D. Brooks - University of PennsylvaniaRichard Sensenig - University of PennsylvaniaGary Friedman - Drexel UniversityZulfiya Orynbayeva - Drexel University
- Publication Details
- PloS one, v 11(6), pp e0156818-e0156818
- Publisher
- Public Library Science
- Number of pages
- 15
- Grant note
- Cornelius Beukenkamp endowment for studies of prostate cancer Mary DeWitt Pettit Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Electrical and Computer Engineering; Surgery
- Web of Science ID
- WOS:000377560200018
- Scopus ID
- 2-s2.0-84974683558
- Other Identifier
- 991019168666304721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology