Journal article
Mitochondria in malaria and related parasites: ancient, diverse and streamlined
Journal of bioenergetics and biomembranes, v 40(5), pp 425-433
Oct 2008
PMID: 18814021
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Parasitic organisms have emerged from nearly every corner of the eukaryotic kingdom and hence display tremendous diversity of form and function. This diversity extends to their mitochondria and mitochondrion-derived organelles. While the principles of the chemiosmotic theory apply to all these pathogens, the differences from their hosts provide opportunities for therapeutic development. In this review we discuss examples of mitochondrial systems from a deep-branching phylum, Apicomplexa. Many important human pathogens, such as malaria parasites, belong to this phylum. Unique features of their mitochondria are validated targets for drugs that are selectively toxic to the parasites.
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Details
- Title
- Mitochondria in malaria and related parasites: ancient, diverse and streamlined
- Creators
- Michael W Mather - Department of Microbiology and Immunology, Center for Molecular Parasitology, Drexel University College of Medicine, Philadelphia, PA 19129, USA. mmather@drexelmed.eduAkhil B Vaidya
- Publication Details
- Journal of bioenergetics and biomembranes, v 40(5), pp 425-433
- Publisher
- Springer Nature; United States
- Grant note
- AI053148 / NIAID NIH HHS R01 AI028398 / NIAID NIH HHS AI028398 / NIAID NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000261179200004
- Scopus ID
- 2-s2.0-57049091041
- Other Identifier
- 991014877961104721
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Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biophysics
- Cell Biology