Journal article
Mitochondria membrane transformations in colon and prostate cancer and their biological implications
Biochimica et biophysica acta. Biomembranes, v 1863(1), pp 183471-183471
01 Jan 2021
PMID: 32931774
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Mitochondria have emerged as important determinants in cancer progression and malignancy. However, the role of mitochondrial membranes in cancer onset and progression has not been thoroughly investigated. This study compares the structural and functional properties of mitochondrial membranes in prostate and colon cancer cells in comparison to normal mitochondria, and possible therapeutic implications of these membrane changes. Specifically, isolation of cell mitochondria and preparation of inverted sub-mitochondrial particles (SMPs) illuminated significant cancer-induced modulations of membrane lipid compositions, fluidity, and activity of cytochrome c oxidase, one of the key mitochondrial enzymes. The experimental data further show that cancer-associated membrane transformations may account for mitochondria targeting by betulinic acid and resveratrol, known anti-cancer molecules. Overall, this study probes the relationship between cancer and mitochondrial membrane transformations, underlying a potential therapeutic significance for mitochondrial membrane targeting in cancer.
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Details
- Title
- Mitochondria membrane transformations in colon and prostate cancer and their biological implications
- Creators
- Shani Ben Zichri - Ben-Gurion University of the NegevSofiya Kolusheva - Ben-Gurion University of the NegevAlexander Shames - Ben-Gurion University of the NegevElina Abaev Schneiderman - Ben-Gurion University of the NegevJuan L. Poggio - Drexel UniversityDavid E. Stein - Drexel UniversityElena Doubijensky - Ben-Gurion University of the NegevDan Levy - Ben-Gurion University of the NegevZulfiya Orynbayeva - Drexel UniversityRaz Jelinek - Ben-Gurion University of the Negev
- Publication Details
- Biochimica et biophysica acta. Biomembranes, v 1863(1), pp 183471-183471
- Publisher
- Elsevier
- Number of pages
- 9
- Grant note
- Louis and Bessie Stein Family Fellowship
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000594121100014
- Scopus ID
- 2-s2.0-85091237860
- Other Identifier
- 991019168881904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Biophysics