Journal article
Mitochondrial Dysfunction in Age-Related Metabolic Disorders
Proteomics (Weinheim), v 20(5-6), pp e1800404-n/a
Mar 2020
PMID: 32131138
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aging is a natural biological process in living organisms characterized by receding bioenergetics. Mitochondria are crucial for cellular bioenergetics and thus an important contributor to age-related energetics deterioration. In addition, mitochondria play a major role in calcium signaling, redox homeostasis, and thermogenesis making this organelle a major cellular component that dictates the fate of a cell. To maintain its quantity and quality, mitochondria undergo multiple processes such as fission, fusion, and mitophagy to eliminate or replace damaged mitochondria. While this bioenergetics machinery is properly protected, the functional decline associated with age and age-related metabolic diseases is mostly a result of failure in such protective mechanisms. In addition, metabolic by-products like reactive oxygen species also aid in this destructive pathway. Mitochondrial dysfunction has always been thought to be associated with diseases. Moreover, studies in recent years have pointed out that aging contributes to the decay of mitochondrial health by promoting imbalances in key mitochondrial-regulated pathways. Hence, it is crucial to understand the nexus of mitochondrial dysfunction in age-related diseases. This review focuses on various aspects of basic mitochondrial biology and its status in aging and age-related metabolic diseases.
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Details
- Title
- Mitochondrial Dysfunction in Age-Related Metabolic Disorders
- Creators
- Venkateswaran Natarajan - National University of SingaporeRitu Chawla - National University of SingaporeTania Mah - National University of SingaporeRajesh Vivekanandan - National University of SingaporeShu Yi Tan - National University of SingaporePriscila Y Sato - Drexel UniversityKarthik Mallilankaraman - National University Health System
- Publication Details
- Proteomics (Weinheim), v 20(5-6), pp e1800404-n/a
- Publisher
- Wiley
- Grant note
- 17SDG33660407 / American Heart Association-American Stroke Association
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000523626700011
- Scopus ID
- 2-s2.0-85082734726
- Other Identifier
- 991019167831204721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemical Research Methods
- Biochemistry & Molecular Biology