Journal article
Mitochondrial Dysfunction in Gliomas
Seminars in pediatric neurology, v 20(3), pp 216-227
01 Sep 2013
PMID: 24331363
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Mitochondrial (mt) dysfunction in gliomas has been linked to abnormalities of mt energy metabolism, marked by a metabolic shift from oxidative phosphorylation to glycolysis ("Warburg effect"), disturbances in mt membrane potential regulation and apoptotic signaling, as well as to somatic mutations involving the Krebs cycle enzyme isocitrate dehydrogenase. Evolving biological concepts with potential therapeutic implications include interaction between microtubule proteins and mitochondria (mt) in the control of closure of voltage-dependent anion channels and in the regulation of mt dynamics and the mt-endoplasmic reticulum network. The cytoskeletal protein beta III-tubulin, which is overexpressed in malignant gliomas, has emerged as a prosurvival factor associated in part with nit and also as a marker of chemoresistance. Mt-targeted therapeutic strategies that are discussed include the following: (1) metabolic modulation with emphasis on dichloroacetate, a pyruvate dehydrogenase kinase inhibitor; (2) tumor cell death via apoptosis induced by tricyclic antidepressants, microtubule-modulating drugs, and small molecules or compounds capable of inflicting reactive oxygen species dependent tumor cell death; and (3) pretreatment mt priming and mt-targeted prodrug cancer therapy. (C) 2013 Elsevier Inc. All rights reserved.
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Details
- Title
- Mitochondrial Dysfunction in Gliomas
- Creators
- Christos D. Katsetos - Drexel UniversityHelen Anni - Temple UniversityPavel Draber - Cytoskeleton (United States)
- Publication Details
- Seminars in pediatric neurology, v 20(3), pp 216-227
- Publisher
- Elsevier
- Number of pages
- 12
- Grant note
- Sbarro Health Research Organization LH12050 / Ministry of Education, Youth and Sports of the Czech Republic; Ministry of Education, Youth & Sports - Czech Republic St. Christopher's Foundation for Children Philadelphia Health Education Corporation St. Christopher's Hospital for Children Reunified Endowment 68378050 / Institutional Research Support (RVO)
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000328262000007
- Scopus ID
- 2-s2.0-84890230915
- Other Identifier
- 991019353729604721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Clinical Neurology
- Pediatrics