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Journal article
Mitochondrial Haplogroup Influences Motor Function in Long-Term HIV-1-Infected Individuals
PloS one, v 11(10), pp e0163772-e0163772
2016
PMID: 27711166
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Evolutionary divergence of the mitochondrial genome has given rise to distinct haplogroups. These haplogroups have arisen in specific geographical locations and are responsible for subtle functional changes in the mitochondria that may provide an evolutionary advantage in a given environment. Based on these functional differences, haplogroups could define disease susceptibility in chronic settings. In this study, we undertook a detailed neuropsychological analysis of a cohort of long-term HIV-1-infected individuals in conjunction with sequencing of their mitochondrial genomes. Stepwise regression analysis showed that the best model for predicting both working memory and declarative memory were age and years since diagnosis. In contrast, years since diagnosis and sub-haplogroup were significantly predictive of psychomotor speed. Consistent with this, patients with haplogroup L3e obtained better scores on psychomotor speed and dexterity tasks when compared to the remainder of the cohort, suggesting that this haplogroup provides a protective advantage when faced with the combined stress of HIV-1 infection and long-term antiretroviral therapies. Differential performance on declarative memory tasks was noted for individuals with other sub-L haplogroups, but these differences were not as robust as the association between L3e and psychomotor speed and dexterity tasks. This work provides evidence that mitochondrial haplogroup is related to neuropsychological test performance among patients in chronic disease settings such as HIV-1 infection.
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Details
- Title
- Mitochondrial Haplogroup Influences Motor Function in Long-Term HIV-1-Infected Individuals
- Creators
- Ashley Azar - Drexel UniversityKathryn Devlin - Temple UniversityJoshua Chang Mell - Drexel UniversityTania Giovannetti - Temple UniversityVanessa Pirrone - Drexel UniversityMichael R Nonnemacher - Drexel UniversityShendra Passic - Drexel UniversityKatherine Kercher - Drexel UniversityJean W Williams - Drexel UniversityJeffery M Jacobson - Temple UniversityBrian Wigdahl - Drexel UniversityWilliam Dampier - Drexel UniversityDavid J Libon - Rowan UniversityChristian Sell - Drexel University
- Publication Details
- PloS one, v 11(10), pp e0163772-e0163772
- Publisher
- Public LIbrary of Science (PLOS)
- Grant note
- R01 DA019807 / NIDA NIH HHS P30 MH092177 / NIMH NIH HHS R01 NS046263 / NINDS NIH HHS R01 NS089435 / NINDS NIH HHS R01 NS032092 / NINDS NIH HHS T32 MH079785 / NIMH NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Psychological and Brain Sciences (Psychology); Microbiology and Immunology; School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000385697600041
- Scopus ID
- 2-s2.0-84990986257
- Other Identifier
- 991019168328604721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Multidisciplinary Sciences