Files and links (1)
Published, Version of Record (VoR)CC BY V4.0, Open
Journal article
Mitochondrial Membrane Intracellular Communication in Healthy and Diseased Myocardium
Frontiers in cell and developmental biology, v 8, pp 609241-609241
23 Dec 2020
PMID: 33425917
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Research efforts in the twenty-first century have been paramount to the discovery and development of novel pharmacological treatments in a variety of diseases resulting in improved life expectancy. Yet, cardiac disease remains a leading cause of morbidity and mortality worldwide. Over time, there has been an expansion in conditions such as atrial fibrillation (AF) and heart failure (HF). Although past research has elucidated specific pathways that participate in the development of distinct cardiac pathologies, the exact mechanisms of action leading to disease remain to be fully characterized. Protein turnover and cellular bioenergetics are integral components of cardiac diseases, highlighting the importance of mitochondria and endoplasmic reticulum (ER) in driving cellular homeostasis. More specifically, the interactions between mitochondria and ER are crucial to calcium signaling, apoptosis induction, autophagy, and lipid biosynthesis. Here, we summarize mitochondrial and ER functions and physical interactions in healthy physiological states. We then transition to perturbations that occur in response to pathophysiological challenges and how this alters mitochondrial–ER and other intracellular organelle interactions. Finally, we discuss lifestyle interventions and innovative therapeutic targets that may be used to restore beneficial mitochondrial and ER interactions, thereby improving cardiac function.
Metrics
Details
- Title
- Mitochondrial Membrane Intracellular Communication in Healthy and Diseased Myocardium
- Creators
- Vishnu K. Kumar - Drexel UniversityAtreju Lackey - Drexel UniversityJonathan Snyder - Drexel UniversitySunil Karhadkar - Temple UniversityAjay D. Rao - Temple UniversityAntonio DiCarlo - Temple UniversityPriscila Y. Sato - Drexel University
- Publication Details
- Frontiers in cell and developmental biology, v 8, pp 609241-609241
- Publisher
- Frontiers Media S.A
- Grant note
- American Heart Association
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000605957700001
- Scopus ID
- 2-s2.0-85099141228
- Other Identifier
- 991019167843404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell Biology
- Developmental Biology