Mitochondrial involvement in myocyte death and heart failure

Michael J Goldenthal

doi:10.1007/s10741-016-9531-1

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Mitochondrial involvement in myocyte death and heart failure

Journal article

Peer reviewed

Mitochondrial involvement in myocyte death and heart failure

Michael J Goldenthal

Heart failure reviews, v 21(2), pp 137-155

Mar 2016

DOI: https://doi.org/10.1007/s10741-016-9531-1

PMID: 26886225

Featured in Collection : UN Sustainable Development Goals @ Drexel

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Abstract

Cell Death

Energy Metabolism

Heart Failure - physiopathology

Heart Failure - therapy

Humans

Mitochondria, Heart - metabolism

Mitochondrial Membrane Transport Proteins

Mitochondrial Permeability Transition Pore

Myocytes, Cardiac - metabolism

Oxidative Stress

Randomized Controlled Trials as Topic

Reactive Oxygen Species - metabolism

As the heart is an energy-demanding organ, impaired cardiac energy metabolism and mitochondrial function have been inexorably linked to cardiac dysfunction. There is a growing recognition that mitochondrial dysfunction contributes to impaired myocardial energetics and increased oxidative stress in cardiomyopathies, cardiac ischemic damage and heart failure (HF), and mitochondrial permeability transition pore opening has been reported a critical trigger of myocyte death and myocardial remodeling. It is well established that mitochondria play pivotal roles in intracellular signaling in both cell death as well as in cardioprotective pathways. Moreover, recent studies have shown that defects in mitochondrial dynamics affecting biogenesis and turnover are linked to cardiac senescence and HF. Accordingly, there has been an increasing interest in targeting mitochondria for HF therapy. This article reviews the background and recent evidence of mitochondrial involvement in several types of cell death (apoptosis, necrosis and autophagy) occurring in HF. In addition, potential strategies for targeting mitochondria are examined, and their utility in HF therapy considered.