Journal article
Mitochondrial responses to organelle-specific drug delivering nanoparticles composed of polypeptide and peptide complexes
Nanomedicine (London, England), v 15(30), pp 2917-2932
01 Oct 2020
PMID: 33241963
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aims: The mechanistic study of the drug carrier-target interactions of mitochondria-unique nanoparticles composed of polypeptide-peptide complexes (mPoP-NPs). Materials & methods: The isolated organelles were employed to address the direct effects of mPoP-NPs on dynamic structure and functional wellbeing of mitochondria. Mitochondria morphology, respiration, membrane potential, reactive oxygen species generation, were examined by confocal microscopy, flow cytometry and oxygraphy. Lonidamine-encapsulated formulation was assessed to evaluate the drug delivery capacity of the naive nanoparticles. Results: The mPoP-NPs do not alter mitochondria structure and performance upon docking to organelles, while successfully delivering drug that causes organelle dysfunction. Conclusion: The study gives insight into interactions of mPoP-NPs with mitochondria and provides substantial support for consideration of designed nanoparticles as biocompatible and efficient mitochondria-targeted platforms.
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Details
- Title
- Mitochondrial responses to organelle-specific drug delivering nanoparticles composed of polypeptide and peptide complexes
- Creators
- Carleigh Charles - Drexel UniversityIfat Cohen-Erez - Ben-Gurion University of the NegevBlake Kazaoka - Drexel UniversityOlga Melnikov - Drexel UniversityDavid E. Stein - Drexel UniversityRichard Sensenig - Cooper University HospitalHanna Rapaport - Ben-Gurion University of the NegevZulfiya Orynbayeva - Drexel University
- Publication Details
- Nanomedicine (London, England), v 15(30), pp 2917-2932
- Publisher
- Future Medicine Ltd
- Number of pages
- 16
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000592403500001
- Scopus ID
- 2-s2.0-85098588996
- Other Identifier
- 991019168901104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biotechnology & Applied Microbiology
- Nanoscience & Nanotechnology