Journal article
Mixed lineage kinase activity of indolocarbazole analogues
Bioorganic & medicinal chemistry letters, v 12(2), pp 147-150
21 Jan 2002
PMID: 11755341
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Abstract
The MLK1–3 activity for a series of analogues of the indolocarbazole K-252a is reported. Addition of 3,9-bis-alkylthiomethyl groups to K-252a results in potent and selective MLK inhibitors. The in vitro and in vivo survival promoting activity of bis-isopropylthiomethyl-K-252a (
16, CEP-11004/KT-8138) is reported.
The MLK1–3 activity for a series of analogues of the indolocarbazole K-252a is reported.
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Details
- Title
- Mixed lineage kinase activity of indolocarbazole analogues
- Creators
- Chikara Murakata - Kyowa Kirin (Japan)Masami Kaneko - Kyowa-Hakko Kogyo Co., Ltd., Tokyo, JapanGeorge Gessner - Department of Biochemistry, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380, USAThelma S Angeles - Department of Biochemistry, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380, USAMark A Ator - Department of Biochemistry, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380, USATeresa M O'Kane - Department of Neurobiology, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380, USABeth Ann W McKenna - Department of Neurobiology, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380, USABeth Ann Thomas - Department of Neurobiology, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380, USAJoanne R Mathiasen - Department of Neurobiology, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380, USAMichael S Saporito - Department of Neurobiology, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380, USADonna Bozyczko-Coyne - Department of Neurobiology, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380, USARobert L Hudkins - Department of Medicinal Chemistry, Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380, USA
- Publication Details
- Bioorganic & medicinal chemistry letters, v 12(2), pp 147-150
- Publisher
- Elsevier
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000173263300010
- Scopus ID
- 2-s2.0-18244379883
- Other Identifier
- 991021900193804721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Chemistry, Medicinal
- Chemistry, Organic