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Journal article
Mixed-mode oscillations and population bursting in the pre-Botzinger complex
eLife, v 5(2016), pp e13403-e13403
14 Mar 2016
PMID: 26974345
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This study focuses on computational and theoretical investigations of neuronal activity arising in the pre-Botzinger complex (pre-BetC), a medullary region generating the inspiratory phase of breathing in mammals. A progressive increase of neuronal excitability in medullary slices containing the pre-BotC produces mixed-mode oscillations (MMOs) characterized by large amplitude population bursts alternating with a series of small amplitude bursts. Using two different computational models, we demonstrate that MMOs emerge within a heterogeneous excitatory neural network because of progressive neuronal recruitment and synchronization. The MMO pattern depends on the distributed neuronal excitability, the density and weights of network interconnections, and the cellular properties underlying endogenous bursting. Critically, the latter should provide a reduction of spiking frequency within neuronal bursts with increasing burst frequency and a dependence of the after-burst recovery period on burst amplitude. Our study highlights a novel mechanism by which heterogeneity naturally leads to complex dynamics in rhythmic neuronal populations.
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Details
- Title
- Mixed-mode oscillations and population bursting in the pre-Botzinger complex
- Creators
- Bartholomew J. Bacak - Drexel UniversityTaegyo Kim - Drexel UniversityJeffrey C. Smith - National Institute of Neurological Disorders and StrokeJonathan E. Rubin - University of PittsburghIlya A. Rybak - Drexel University
- Publication Details
- eLife, v 5(2016), pp e13403-e13403
- Publisher
- Elife Sciences Publications Ltd
- Number of pages
- 26
- Grant note
- DMS-1312508 / National Science Foundation; National Science Foundation (NSF) NS069220 / National Institute of Neurological Disorders and Stroke; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01NS069220 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000387451900001
- Scopus ID
- 2-s2.0-84964282364
- Other Identifier
- 991019169545404721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biology