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Mixtures of key components of the external exposome in association with MRI biomarkers of brain structure: Multi-Ethnic Study of Atherosclerosis
Journal article   Open access   Peer reviewed

Mixtures of key components of the external exposome in association with MRI biomarkers of brain structure: Multi-Ethnic Study of Atherosclerosis

Cameron J Reimer, Tara E Jenson, Yorghos Tripodis, Koichiro Shiba, Peter James, Kipruto Kirwa, Susan R Heckbert, Jana A Hirsch, Lilah Besser, Timothy Hughes, …
Alzheimer's & dementia, v 22(5), e71459
May 2026
DOI: https://doi.org/10.1002/alz.71459
PMID: 42157022
url
https://doi.org/10.1002/alz.71459View
Published, Version of Record (VoR) Restricted CC BY-NC-ND V4.0

Abstract

Aged Aged, 80 and over Atherosclerosis - diagnostic imaging Atherosclerosis - ethnology Brain - diagnostic imaging Brain - pathology Environmental Exposure - adverse effects Ethnicity Female Gray Matter - diagnostic imaging Gray Matter - pathology Humans Male Risk Factors White Matter - diagnostic imaging White Matter - pathology Biomarkers Magnetic Resonance Imaging
There is a critical need to identify risk factors of Alzheimer's disease and related dementias (ADRD). We included 1227 participants (mean age [standard deviation]: 74.1 [7.9] years) from the Multi-Ethnic Study of Atherosclerosis with brain MRI scans. We investigated joint associations of 13 natural, social, and built-environment exposures with gray matter volume (GMV) (n = 1219), white matter fractional anisotropy (WM FA) (n = 1102), and white matter hyperintensity volume (n = 1210) using weighted quantile sum regression. A one-decile increase in all harmful exposures was associated with lower GMV and WM FA; however, associations were null when adjusting for study site. Examining the impact of many environmental factors simultaneously may provide insight into important modifiable risk factors for ADRD, capturing concomitant exposures as they are experienced.

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