Journal article
Mode of action of taurine as a neuroprotector
Brain research, v 1038(2), pp 123-131
21 Mar 2005
PMID: 15757628
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Previously, it has been shown that taurine exerts its protective function against glutamate-induced neuronal excitotoxicity through its action in reducing glutamate-induced elevation of intracellular free calcium, [Ca
2+]
i. Here, we report the mechanism underlying the effect of taurine in reducing [Ca
2+]
i. We found that taurine inhibited glutamate-induced calcium influx through L-, P/Q-, N-type voltage-gated calcium channels (VGCCs) and NMDA receptor calcium channel. Surprisingly, taurine had no effect on calcium influx through NMDA receptor calcium channel when cultured neurons were treated with NMDA in Mg
2+-free medium. Since taurine was found to prevent glutamate-induced membrane depolarization, we propose that taurine protects neurons against glutamate excitotoxicity by preventing glutamate-induced membrane depolarization, probably through its effect in opening of chloride channels and, therefore, preventing the glutamate-induced increase in calcium influx and other downstream events.
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Details
- Title
- Mode of action of taurine as a neuroprotector
- Creators
- Heng Wu - Florida Atlantic UniversityYing Jin - Florida Atlantic UniversityJianning Wei - Florida Atlantic UniversityHong Jin - University of KansasDi Sha - Florida Atlantic UniversityJang-Yen Wu - Florida Atlantic University
- Publication Details
- Brain research, v 1038(2), pp 123-131
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000228195700001
- Scopus ID
- 2-s2.0-14744290779
- Other Identifier
- 991020545237704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences