Journal article
Modeling the ponto-medullary respiratory network
Respiratory physiology & neurobiology, v 143(2)
2004
PMID: 15519563
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The generation and shaping of the respiratory motor pattern are performed in the lower brainstem and involve neuronal interactions within the medulla and between the medulla and pons. A computational model of the ponto-medullary respiratory network has been developed by incorporating existing experimental data on the medullary neural circuits and possible interactions between the medulla and pons. The model reproduces a number of experimental findings concerning alterations of the respiratory pattern following various perturbations/stimulations applied to the pons and pulmonary afferents. The results of modeling support the concept that eupneic respiratory rhythm generation requires contribution of the pons whereas a gasping-like rhythm (and the rhythm observed in vitro) may be generated within the medulla and involve pacemaker-driven mechanisms localized within the medullary pre-Bötzinger Complex. The model and experimental data described support the concept that during eupnea the respiration-related pontine structures control the medullary network mechanisms for respiratory phase transitions, suppress the intrinsic pacemaker-driven oscillations in the pre-BötC and provide inspiration-inhibitory and expiration-facilitatory reflexes which are independent of the pulmonary Hering–Breuer reflex but operate through the same medullary phase switching circuits.
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Details
- Title
- Modeling the ponto-medullary respiratory network
- Creators
- I.A Rybak - School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USAN.A Shevtsova - School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USAJ.F.R Paton - Department of Physiology, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, UKT.E Dick - Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USAW.M St.-John - Department of Physiology, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USAM Mörschel - Department of Physiology, University of Göttingen, Humboldtallee 23, Göttingen 37073, GermanyM Dutschmann - Department of Physiology, University of Göttingen, Humboldtallee 23, Göttingen 37073, Germany
- Publication Details
- Respiratory physiology & neurobiology, v 143(2)
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000225367200017
- Scopus ID
- 2-s2.0-7044263306
- Other Identifier
- 991014877955704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Physiology
- Respiratory System