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Modelling of bone fracture and strength at different length scales: a review
Journal article   Open access   Peer reviewed

Modelling of bone fracture and strength at different length scales: a review

Fereshteh A. Sabet, Ahmad Raeisi Najafi, Elham Hamed and Iwona Jasiuk
Interface focus, v 6(1), 20150055
06 Feb 2016
PMID: 26855749
url
https://europepmc.org/articles/pmc4686238View
Published, Version of Record (VoR)Open Access (License Unspecified) Open
url
https://doi.org/10.1098/rsfs.2015.0055View
Published, Version of Record (VoR) Open

Abstract

1004 bone fracture bone strength computational modelling hierarchical structure Mineral–Collagen Interactions multiscale modelling Part III Review
In this paper, we review analytical and computational models of bone fracture and strength. Bone fracture is a complex phenomenon due to the composite, inhomogeneous and hierarchical structure of bone. First, we briefly summarize the hierarchical structure of bone, spanning from the nanoscale, sub-microscale, microscale, mesoscale to the macroscale, and discuss experimental observations on failure mechanisms in bone at these scales. Then, we highlight representative analytical and computational models of bone fracture and strength at different length scales and discuss the main findings in the context of experiments. We conclude by summarizing the challenges in modelling of bone fracture and strength and list open topics for scientific exploration. Modelling of bone, accounting for different scales, provides new and needed insights into the fracture and strength of bone, which, in turn, can lead to improved diagnostic tools and treatments of bone diseases such as osteoporosis.

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Web of Science research areas
Biology
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