Journal article
Modelling spinal circuitry involved in locomotor pattern generation: insights from the effects of afferent stimulation
The Journal of physiology, v 577(Pt 2), pp 641-658
01 Dec 2006
PMID: 17008375
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
A computational model of the mammalian spinal cord circuitry incorporating a two-level central pattern generator (CPG) with separate half-centre rhythm generator (RG) and pattern formation (PF) networks has been developed from observations obtained during fictive locomotion in decerebrate cats. Sensory afferents have been incorporated in the model to study the effects of afferent stimulation on locomotor phase switching and step cycle period and on the firing patterns of flexor and extensor motoneurones. Here we show that this CPG structure can be integrated with reflex circuits to reproduce the reorganization of group I reflex pathways occurring during locomotion. During the extensor phase of fictive locomotion, activation of extensor muscle group I afferents increases extensor motoneurone activity and prolongs the extensor phase. This extensor phase prolongation may occur with or without a resetting of the locomotor cycle, which (according to the model) depends on the degree to which sensory input affects the RG and PF circuits, respectively. The same stimulation delivered during flexion produces a temporary resetting to extension without changing the timing of following locomotor cycles. The model reproduces this behaviour by suggesting that this sensory input influences the PF network without affecting the RG. The model also suggests that the different effects of flexor muscle nerve afferent stimulation observed experimentally (phase prolongation versus resetting) result from opposing influences of flexor group I and II afferents on the PF and RG circuits controlling the activity of flexor and extensor motoneurones. The results of modelling provide insights into proprioceptive control of locomotion.
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Details
- Title
- Modelling spinal circuitry involved in locomotor pattern generation: insights from the effects of afferent stimulation
- Creators
- Ilya A Rybak - Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USAKatinka StecinaNatalia A ShevtsovaDavid A McCrea
- Publication Details
- The Journal of physiology, v 577(Pt 2), pp 641-658
- Publisher
- England
- Grant note
- R01NS048844 / NINDS NIH HHS R01HL072415 / NHLBI NIH HHS R01NS046062 / NINDS NIH HHS R01 NS040846 / NINDS NIH HHS R01 NS048844 / NINDS NIH HHS R01 HL072415 / NHLBI NIH HHS R01 NS046062 / NINDS NIH HHS R01NS040846 / NINDS NIH HHS R01 NS048844-02 / NINDS NIH HHS R01 NS048844-01A2 / NINDS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000242240900014
- Scopus ID
- 2-s2.0-33751337094
- Other Identifier
- 991014877651304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences
- Physiology