State-scale and premises-scale gravity models for the spread of highly pathogenic avian influenza (H5N1) in Nigeria and Ghana were used to provide a basis for risk maps for future epidemics and to compare and rank plausible culling and vaccination strategies for control. Maximum likelihood methods were used to fit the models to the 2006-2007 outbreaks. The sensitivity and specificity of the state-scale model-generated probabilities that any given state would be involved in an epidemic were each 57 %. The premises-based model indicated that reactive, countrywide vaccination strategies, in which the order in which flocks are vaccinated was strictly determined by known risk factors for infection, were more effective in reducing the final size of the epidemic and the epidemic impact than vaccinating flocks at random or ring vaccination. The model suggests that an introduction of highly pathogenic avian influenza (H5N1) into Ghana had a high chance (84 %) of causing a major outbreak. That this did not happen was most probably a result of the very swift Ghanaian response to news of the first introductions.
Models of highly pathogenic avian influenza epidemics in commercial poultry flocks in Nigeria and Ghana
Creators
Sky T. K. Pelletier - University of Pennsylvania
Chris Rorres - University of Pennsylvania
Peter C. Macko - University of Pennsylvania
Sarah Peters - University of Pennsylvania
Gary Smith - University of Pennsylvania
Publication Details
Tropical animal health and production, v 44(7), pp 1681-1687
Publisher
Springer Nature
Number of pages
7
Grant note
5U01GM-076426 / National Institute of General Medical Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
T35OD010919 / OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
International Food Policy Research Institute, Washington, DC
U01GM076426 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
Resource Type
Journal article
Language
English
Academic Unit
[Retired Faculty]
Web of Science ID
WOS:000308359100051
Scopus ID
2-s2.0-84866169842
Other Identifier
991021879780704721
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