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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Moderate Alcohol Consumption and Chronic Disease: The Case for a Long‐Term Trial
Alcoholism, clinical and experimental research, v 40(11), pp 2283-2291
Nov 2016
PMID: 27688006
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Drinking within recommended limits is highly prevalent in much of the world, and strong epidemiological associations exist between moderate alcohol consumption and risk of several major chronic diseases, including coronary heart disease, diabetes, and breast cancer. In many cases, plausible biological mediators for these associations have been identified in randomized trials, but gold standard evidence that moderate drinking causes or prevents any chronic disease remains elusive and important concerns about available evidence have been raised. Although long‐term randomized trials to test the observed associations have been termed impossible, clinical investigators have now successfully completed randomized trials of complex nutritional interventions in a variety of settings, along with trials of alcohol consumption itself of up to 2 years duration. The successful completion of these trials suggests that objections to the execution of a full‐scale, long‐term clinical trial of moderate drinking on chronic disease are increasingly untenable. We present potential lessons learned for such a trial and discuss key features to maximize its feasibility and value.
The effects of moderate alcohol consumption on health remain enormously controversial, but no long‐term randomized trial to address this controversy has ever been attempted. However, feeding studies with alcohol of up to 2 years duration have now been completed, as have long‐term randomized trials of the effects of complete diets on chronic disease. These facts argue that a definitive trial of moderate alcohol consumption is feasible and provides tangible lessons for the design of such a trial.
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Details
- Title
- Moderate Alcohol Consumption and Chronic Disease: The Case for a Long‐Term Trial
- Creators
- Kenneth J. Mukamal - Beth Israel Deaconess Medical CenterCatherine M. Clowry - Beth Israel Deaconess Medical CenterMargaret M. Murray - National Institute on Alcohol Abuse and AlcoholismHenk F.J. Hendriks - Hendriks Nutrition Support for Business, Zeist, the Netherlands.Eric B. Rimm - Harvard UniversityKaycee M. Sink - Wake Forest UniversityClement A. Adebamowo - University of Maryland, BaltimoreLars O. Dragsted - University of CopenhagenP. Scott Lapinski - Boston Public LibraryMariana Lazo - Johns Hopkins MedicineJohn H. Krystal - Yale University
- Publication Details
- Alcoholism, clinical and experimental research, v 40(11), pp 2283-2291
- Publisher
- Wiley
- Number of pages
- 9
- Grant note
- National Institute on Alcohol Abuse and Alcoholism (U13AA023452; U34AA023258; U10AA025286)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000386918400003
- Scopus ID
- 2-s2.0-84991782460
- Other Identifier
- 991020550497304721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Substance Abuse