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Moderate weight loss in obese and overweight men preserves bone quality
Journal article   Open access   Peer reviewed

Moderate weight loss in obese and overweight men preserves bone quality

L Claudia Pop, Deeptha Sukumar, Katherine Tomaino, Yvette Schlussel, Stephen H Schneider, Chris L Gordon, Xiangbing Wang and Sue A Shapses
The American journal of clinical nutrition, v 101(3), pp 659-667
Mar 2015
DOI: https://doi.org/10.3945/ajcn.114.088534
PMID: 25733651
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.3945/ajcn.114.088534View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open

Abstract

Absorptiometry, Photon Aged Behavior Therapy Body Mass Index Bone Density Bone Resorption - diagnostic imaging Bone Resorption - epidemiology Bone Resorption - etiology Bone Resorption - prevention & control Caloric Restriction - adverse effects Combined Modality Therapy - adverse effects Diet, Reducing - adverse effects Humans Male Middle Aged Motor Activity New Jersey - epidemiology Nutritional Sciences - education Obesity - diet therapy Obesity - physiopathology Obesity - therapy Overweight - diet therapy Overweight - physiopathology Overweight - therapy Patient Education as Topic Risk Tibia - diagnostic imaging Weight Loss
Weight loss (WL) negatively affects bone mineral density (BMD) in older populations and has specifically been shown in women. In this prospective controlled trial, we examined variables of bone quality and endocrine changes after intentional WL in men. Thirty-eight overweight and obese [mean ± SD body mass index (in kg/m²): 31.9 ± 4.4; age: 58 ± 6 y] men were recruited to either WL through caloric restriction or weight maintenance (WM) for 6 mo. There was a -7.9 ± 4.4% and +0.2 ± 1.6% change in body weight in the WL and WM groups, respectively. There was a greater increase in femoral neck and total body BMD and bone mineral content (BMC) in the WM group than in the WL group (P-interaction effect < 0.05). In contrast, there was a trend for the tibia cortical thickness and area to decrease more in the WM group than in the WL group (P ≤ 0.08). There was a decrease in the periosteal circumference in both groups over time (P < 0.01) and no statistically significant changes in trabecular bone. Circulating total, free, and bioavailable estradiol decreased in the WL group compared with the WM group, and changes were different between groups (P < 0.05). Serum total and bioavailable testosterone increased in both groups (P < 0.01). Serum 25-hydroxyvitamin D increased to a similar extent in both groups (P < 0.05). Moderate WL in overweight and obese men did not decrease BMD at any anatomical site or alter cortical and trabecular bone and geometry. Also, despite increased BMD at some sites when maintaining excess body weight, cortical bone showed a trend in the opposite direction.

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38 citations in Web of Science
38 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being
#5 Gender Equality

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Nutrition & Dietetics
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