Journal article
Modern prevalence of the Fredrickson-Levy-Lees dyslipidemias: findings from the Very Large Database of Lipids and National Health and Nutrition Examination Survey
Archives of medical science, v 16(6), pp 1279-1287
2020
PMID: 33224326
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Introduction: Five decades ago, Fredrickson, Levy, and Lees (FLL) qualitatively characterized clinical dyslipidemias with specific implications for cardiovascular and non-cardiovascular morbidity and mortality. They separated disorders of elevated cholesterol and triglycerides into five phenotypes (types I V) based on their lipoprotein profile. Although clinicians generally consider them rare entities, modern FLL prevalence may be greater than previously reported.
Material and methods: We performed a cross-sectional analysis in 5,272 participants from the 2011-2014 National Health and Nutrition Examination Survey and 128,506 participants from the Very Large Database of Lipids study with complete, fasting lipid profiles. We used a validated algorithm to define FLL phenotypes employing apolipoprotein B, total cholesterol, and triglycerides.
Results: Overall prevalence of FLL phenotypes was 33.9%. FLL prevalence in the general population versus clinical lipid database was: type I (0.05 vs. 0.02%), type Ila (3.2 vs. 3.9%), type Ilb (8.0 vs. 10.3%), type III (2.0 vs. 1.7%), type IV (20.5 vs. 24.1%), and type V (0.15 vs. 0.13%). Those aged 40-74 years had a higher overall prevalence compared to other age groups (p < 0.001) and men had overall higher prevalence than women (p < 0.001). Those with diabetes (51.6%) or obese BMI (49.0%) had higher prevalence of FLL phenotypes compared to those without diabetes (31.3%; p < 0.001) and normal BMI (18.3%; p < 0.001).
Conclusions: FLL phenotypes are likely far more prevalent than appreciated in clinical practice, in part due to diabetes and obesity epidemics. Given the prognostic and therapeutic importance of these phenotypes, their identification becomes increasingly important in the era of precision medicine.
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Details
- Title
- Modern prevalence of the Fredrickson-Levy-Lees dyslipidemias: findings from the Very Large Database of Lipids and National Health and Nutrition Examination Survey
- Creators
- Vasanth Sathiyakumar - Johns Hopkins UniversityVincent A. Pallazola - Johns Hopkins UniversityJihwan Park - Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USARachit M. Vakil - Johns Hopkins UniversityPeter P. Toth - Johns Hopkins UniversityMariana Lazo-Elizondo - Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USARenato Quispe - Johns Hopkins UniversityEliseo Guallar - Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USAMaciej Banach - University of Zielona GóraRoger S. Blumenthal - Johns Hopkins UniversitySteven R. Jones - Johns Hopkins UniversitySeth S. Martin - Johns Hopkins University
- Publication Details
- Archives of medical science, v 16(6), pp 1279-1287
- Publisher
- Termedia Publishing House Ltd
- Number of pages
- 9
- Grant note
- CASCADE FH Maryland Innovation Initiative Google; Google Incorporated Nokia; Nokia Corporation Apple David and June Trone Family Foundation American Heart Association Stanford MedX PJ Schafer Cardiovascular Research Fund iHealth Aetna Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000585918400002
- Scopus ID
- 2-s2.0-85096783133
- Other Identifier
- 991020550338704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cardiac & Cardiovascular Systems