Journal article
Modifiable kidney disease risk factors among nondiabetic adults with obesity from the Multi‐Ethnic Study of Atherosclerosis
Obesity (Silver Spring, Md.)
28 Sep 2023
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Abstract Objective It is unknown whether weight change or physical fitness is associated with chronic kidney disease (CKD) risk among nondiabetic adults with obesity. Methods This was a prospective, longitudinal cohort study of adults with obesity without baseline CKD or diabetes enrolled in the Multi‐Ethnic Study of Atherosclerosis (MESA). Linear mixed‐effects and multistate models were adjusted for demographics, time‐varying covariates including blood pressure, and comorbidities these were used to examine associations of weight change and slow walking pace (<2 miles/h) with (i) rate of annual estimated glomerular filtration rate (eGFR) decline and (ii) incident CKD, defined as eGFR Cr‐Cys < 60 mL/min/1.73 m 2 , and tested for interaction by baseline hypertension status. Results Among 1208 included MESA participants (median BMI 33.0 kg/m 2 [interquartile range 31.2–35.9]), 15% developed CKD. Slow walking pace was associated with eGFR decline (−0.27 mL/min/1.73 m 2 /year; 95% CI: −0.42 to −0.12) and CKD risk (adjusted hazard ratio 1.48; 95% CI: 1.08 to 2.01). Weight gain was associated with CKD risk (adjusted hazard ratio 1.34; 95% CI: 1.02 to 1.78 per 5 kg weight gain from baseline). There was no significant interaction by baseline hypertension status. Conclusions Slow walking pace and weight gain were associated with CKD risk among adults with obesity who did not have diabetes at baseline.
Metrics
Details
- Title
- Modifiable kidney disease risk factors among nondiabetic adults with obesity from the Multi‐Ethnic Study of Atherosclerosis
- Creators
- Meera N. Harhay - Drexel UniversityYuna Kim - Drexel UniversityKari Moore - Drexel UniversityMichael O. Harhay - University of PennsylvaniaRonit Katz - University of WashingtonMichael G. Shlipak - San Francisco VA Health Care SystemHolly J. Mattix-Kramer - Loyola University Chicago
- Publication Details
- Obesity (Silver Spring, Md.)
- Publisher
- Wiley
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Urban Health Collaborative; Epidemiology and Biostatistics; SOM Dean - Research Administration
- Web of Science ID
- WOS:001073765500001
- Scopus ID
- 2-s2.0-85173099652
- Other Identifier
- 991021229975204721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Endocrinology & Metabolism
- Nutrition & Dietetics