Journal article
Modulation of Immune Responses by Exosomes Derived from Antigen-Presenting Cells
CLINICAL MEDICINE INSIGHTS- PATHOLOGY, v 9(Suppl. 1), pp 1-8
01 Jan 2016
PMID: 27660518
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Exosome-mediated signaling is important in mediating the inflammatory response. To exert their biological or pathophysiological functions in the recipient cells, exosomes deliver a diverse array of biomacromolecules including long and short coding and non-coding RNAs, proteins, and lipids. Exosomes secreted by antigen-presenting cells can confer therapeutic benefits by attenuating or stimulating the immune response. Exosomes play a crucial role in carrying and presenting functional major histocompatibility peptide complexes to modulate antigen-specific T cell responses. Exosomes from Dendritic Cells (DCs) can activate T and B cells and have been explored for their immunostimulatory properties in cancer therapy. The immuno-suppressive properties of exosomes derived from macrophages and DCs can reduce inflammation in animal models for several inflammatory disorders. This review focuses on the protective role of exosomes in attenuating inflammation or augmenting immune response, emphasizing studies on exosomes derived from DCs and macrophages.
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Details
- Title
- Modulation of Immune Responses by Exosomes Derived from Antigen-Presenting Cells
- Creators
- Botros B. Shenoda - Drexel UniversitySeena K. Ajit - Drexel University
- Publication Details
- CLINICAL MEDICINE INSIGHTS- PATHOLOGY, v 9(Suppl. 1), pp 1-8
- Publisher
- Sage
- Number of pages
- 8
- Grant note
- Drexel Clinical & Translational Research Institute Fulbright Foreign Student Program fellowship funded by the US Department of State, Bureau of Educational and Cultural Affairs NINDS 1R21NS082991-01 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Dean's Fellowship for Excellence in Collaborative or Themed Research, Graduate School of Biomedical Sciences and Professional Studies, Drexel University College of Medicine R21NS082991 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000389439300001
- Scopus ID
- 2-s2.0-84995394508
- Other Identifier
- 991019167618104721
UN Sustainable Development Goals (SDGs)
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Source: SDGs in the Output
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Pathology