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Journal article
Modulation of Spinal Motor Output by Initial Arm Postures in Anesthetized Monkeys
The Journal of neuroscience, v 35(17), pp 6937-6945
29 Apr 2015
PMID: 25926468
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Proper execution of voluntary movement requires a sensorimotor transformation based on the initial limb state. For example, successfully reaching to a stable target requires the recruitment of different muscle groups depending on limb position at movement initiation. To test whether this transformation could occur at the spinal level, we stimulated the cervical spinal cord of anesthetized monkeys while systematically changing initial posture and examined the modulation of the twitch response induced in the upper limb muscles. In three monkeys, a multichannel microelectrode array was implanted into the C6 segment of the spinal cord and electromyographic electrodes were implanted in 12 limb muscles (five hand, four elbow, and three shoulder muscles). The magnitude and onset latency of the evoked response in each electrode-muscle pair were examined by systematically changing the hand position through nine positions in a horizontal plane with the monkey prone. Among 330 electrode-muscle pairs examined, 61% of pairs exhibited significant modulation of either magnitude or latency of twitch responses across different hand/arm configurations (posture dependency). We found that posture dependency occurred preferentially in the distal rather than proximal muscles and was not affected by the location of the electrode within the stimulated spinal segment. Importantly, this posture dependency was not affected by spinalization at the C2 level. These results suggest that excitability in the cervical spinal cord is affected by initial arm posture through spinal reflex pathways. This posture dependency of spinal motor output could affect voluntary arm movement by adjusting descending motor commands relative to the initial arm posture.
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Details
- Title
- Modulation of Spinal Motor Output by Initial Arm Postures in Anesthetized Monkeys
- Creators
- Hiroaki Yaguchi - The University of TokyoTomohiko Takei - National Center of Neurology and PsychiatryDavid Kowalski - Drexel Univ, Sch Biomed Engn Sci & Hlth Syst, Philadelphia, PA 19104 USATakafumi Suzuki - National Institute of Information and Communications TechnologyKunihiko Mabuchi - The University of TokyoKazuhiko Seki - Japan Science and Technology Agency
- Publication Details
- The Journal of neuroscience, v 35(17), pp 6937-6945
- Publisher
- Soc Neuroscience
- Number of pages
- 9
- Grant note
- OISE-1108063 / National Science Foundation; National Science Foundation (NSF) Japan Science and Technology Agency Precursory Research for Embryonic Science and Technology program; Japan Science & Technology Agency (JST) 18020030; 18047027; 26120003 / Ministry of Education, Culture, Sports, Science and Technology of Japan; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) 26250013 / Grants-in-Aid for Scientific Research; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT); Japan Society for the Promotion of Science; Grants-in-Aid for Scientific Research (KAKENHI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000353647600027
- Scopus ID
- 2-s2.0-84929353675
- Other Identifier
- 991021883114804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences