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Journal article
Modulation of inflammation in wounds of diabetic patients treated with porcine urinary bladder matrix
Regenerative medicine, v 14(4)
01 Apr 2019
PMID: 31020913
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Aim: To determine if porcine urinary bladder matrix (UBM) treatment is associated with modulation of wound inflammation in diabetic patients. Patients & methods: mRNA associated with M1 and M2 macrophages were measured in wounds of diabetic and nondiabetic patients pre-and post-treatment with UBM and an M1: M2 score was calculated. Results: Wound tissue from diabetic subjects exhibited elevated M1: M2 scores compared with nondiabetic patients, suggesting a greater pro-inflammatory state prior to treatment. Post-treatment, there was significantly greater reduction in the magnitude of the individual M1: M2 scores in the diabetic patients resulting in similar levels in both groups of patients. Conclusions: UBM may assist in diabetic wound healing by restoring an inflammatory state similar to that of nondiabetic patients.
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Details
- Title
- Modulation of inflammation in wounds of diabetic patients treated with porcine urinary bladder matrix
- Creators
- John T. Paige - Louisiana State University Health Sciences Center New OrleansMichael Kremer - Tulane UniversityJace Landry - Louisiana State University Health Sciences Center New OrleansSamuel A. Hatfield - Tulane UniversityDonald Wathieu - Tulane UniversityAaron Brug - Tulane UniversityDaniel J. Lightell - Tulane UniversityKara L. Spiller - Drexel UniversityT. Cooper Woods - Tulane University
- Publication Details
- Regenerative medicine, v 14(4)
- Publisher
- Future Medicine Ltd
- Number of pages
- 9
- Grant note
- ACell, Inc. P30GM103337 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) P30GM103337 / National Institutes of General Medical Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) R01HL127092 / NIH through the National Heart Lung & Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01HL127092 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000476569600003
- Scopus ID
- 2-s2.0-85067390245
- Other Identifier
- 991019169549704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Cell & Tissue Engineering
- Engineering, Biomedical