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Journal article
Molecular Biomarkers and Epidemiologic Risk Assessment
Human and ecological risk assessment, v 8(6), pp 1295-1301
01 May 2002
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The use of molecular biomarkers in epidemiologic studies has been advancedas a way to improve risk assessments for occupational and environmental exposuresto toxic agents. We have used the detection of two cancer-related, molecular biomarkers of vinyl chloride exposure (mutant ras-p21 and mutant p53) to examine workers with equivalent cumulative exposures that would be above or below the current permissible workplace exposure limit for vinyl chloride for differences in the presence of these biomarkers. Workers with cumulative exposures above the current permissible exposure limit (equivalent of > 40 ppm-years) have a statistically significantly increased occurrence of both biomarkers in comparison to unexposed controls (p < 10
−3
). Although workers with cumulative exposures of < 10 ppm-years, i.e., well below the current limit, do not have a statistically significantly increased occurrence of these biomarkers (p > 0.05), workers with cumulative exposures of 10 to 40 ppm-years, i.e., still below the current limit, are found to have a statistically significant increase (p < 0.05). This suggests that the current exposure limit may not be adequately protective and illustrates the potential utility of molecular biomarkers in the refinement of risk assessments for toxic exposures.
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Details
- Title
- Molecular Biomarkers and Epidemiologic Risk Assessment
- Creators
- Paul W. Brandt-Rauf - Mailman School of Public HealthJiin-Chyuan Luo - Chang Gung UniversityTsun-Jen Cheng - National Taiwan UniversityChung-Li Du - National Taiwan UniversityJung-Der Wang - 公共衛生學科暨研究所Ramon Rosal - Mailman School of Public HealthTamara Do - Mailman School of Public HealthMarie-Jeanne Marion - Institut National de la Sante et de la Recherche Medicale
- Publication Details
- Human and ecological risk assessment, v 8(6), pp 1295-1301
- Publisher
- TAYLOR & FRANCIS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:000179095200009
- Scopus ID
- 2-s2.0-26844490184
- Other Identifier
- 991019323776004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biodiversity Conservation
- Environmental Sciences