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Journal article
Molecular Determinants of the Axonal mRNA Transcriptome
Developmental neurobiology (Hoboken, N.J.), v 74(3), pp 218-232
Mar 2014
PMID: 23959706
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Axonal protein synthesis has been shown to play a role in developmental and regenerative growth, as well as in cell body responses to axotomy. Recent studies have begun to identify the protein products that contribute to these autonomous responses of axons. In the peripheral nervous system, intra-axonal protein synthesis has been implicated in the localized in vivo responses to neuropathic stimuli, and there is emerging evidence for protein synthesis in CNS axons in vivo. Despite that hundreds of mRNAs have now been shown to localize into the axonal compartment, knowledge of what RNA binding proteins are responsible for this is quite limited. Here, we review the current state of knowledge of RNA transport mechanisms and highlight recently uncovered mechanisms for dynamically altering the axonal transcriptome. Both changes in the levels or activities of components of the RNA transport apparatus and alterations in transcription of transported mRNAs can effectively shift the axonal mRNA population. Consistent with this, the axonal RNA population shifts with development, with changes in growth state, and in response to extracellular stimulation. Each of these events must impact the transcriptional and transport apparatuses of the neuron, thus directly and indirectly modifying the axonal transcriptome.
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Details
- Title
- Molecular Determinants of the Axonal mRNA Transcriptome
- Creators
- Cynthia Gomes - Drexel Univ, Dept Biol, Philadelphia, PA 19104 USATanuja T. Merianda - Drexel Univ, Dept Biol, Philadelphia, PA 19104 USASeung Joon Lee - Drexel UniversitySoonmoon Yoo - Alfred I duPont Hosp Children, Wilmington, DE 19803 USAJeffery L. Twiss - Drexel University
- Publication Details
- Developmental neurobiology (Hoboken, N.J.), v 74(3), pp 218-232
- Publisher
- Wiley
- Number of pages
- 15
- Grant note
- P20GM103464 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) Dr. Miriam and Sheldon G. Adelson Medical Research Foundation R01NS041596 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) P20RR020173 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) R01-NS041596; P20-RR020173 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA MCB-1020970 / National Science Foundation; National Science Foundation (NSF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000330854500003
- Scopus ID
- 2-s2.0-84893780287
- Other Identifier
- 991021892010704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Developmental Biology
- Neurosciences