Journal article
Molecular Epidemiology of Foodborne Hepatitis A Outbreaks in the United States, 2003
The Journal of infectious diseases, v 192(8), pp 1323-1330
15 Oct 2005
PMID: 16170748
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
BackgroundMolecular epidemiologic investigations can link geographically separate foodborne hepatitis A outbreaks but have not been used while field investigations are in progress. In 2003, outbreaks of foodborne hepatitis A were reported in multiple states MethodsCase-control studies were conducted in 3 states. Hepatitis A virus was sequenced from serologic specimens from individuals associated with outbreaks and from individuals concurrently ill with hepatitis A in nonoutbreak settings in the United States and Mexico ResultsCase-control studies in Tennessee (TN), North Carolina (NC), and Georgia (GA) found green onions to be associated with illness among restaurant patrons (TN: odds ratio [OR], 65.5 [95% confidence interval {CI}, 8.9–482.5; NC: OR, 2.4 [95% CI, 0.3–21.9]; GA: OR, 20.9 [95% CI, 3.9–110.3]). Viral sequences from TN case patients differed by 2 nt, compared with those from case patients in NC and GA. A third sequence, differing from the TN and GA/NC sequences by 1 nt, was identified among case patients in a subsequent outbreak in Pennsylvania. Each outbreak sequence was identical to ⩾1 sequence isolated from northern Mexican resident(s) with hepatitis A. The sources of green onions served in restaurants in TN and GA were 3 farms in northern Mexico ConclusionsOngoing viral strain surveillance facilitated the rapid implementation of control measures. Incorporation of molecular epidemiologic methods into routine hepatitis A surveillance would improve the detection of hepatitis A outbreaks and increase our understanding of hepatitis A epidemiology in the United States
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Details
- Title
- Molecular Epidemiology of Foodborne Hepatitis A Outbreaks in the United States, 2003
- Creators
- Joseph J. Amon - Epidemic Intelligence ServiceRose Devasia - Tennessee Department of HealthGuoliang Xia - National Center for Infectious DiseasesOmana V. Nainan - National Center for Infectious DiseasesStephanie Hall - Knox County SchoolsBrian Lawson - Knox County SchoolsJulie S. Wolthuis - Georgia Department of Public HealthPia D. M. MacDonald - North Carolina Division of Public HealthColin W. Shepard - National Center for Infectious DiseasesIan T. Williams - National Center for Infectious DiseasesGregory L. Armstrong - National Center for Infectious DiseasesJulie A. Gabel - Georgia Department of Public HealthPaul Erwin - Tennessee Department of HealthLorinda Sheeler - Tennessee Department of HealthWendi Kuhnert - National Center for Infectious DiseasesPriti Patel - National Center for Infectious DiseasesGilberto Vaughan - National Center for Infectious DiseasesAndre Weltman - Pennsylvania Department of HealthAllen S. Craig - Tennessee Department of HealthBeth P. Bell - National Center for Infectious DiseasesAnthony Fiore - National Center for Infectious Diseases
- Publication Details
- The Journal of infectious diseases, v 192(8), pp 1323-1330
- Publisher
- The University of Chicago Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Community Health and Prevention
- Web of Science ID
- WOS:000232002200004
- Scopus ID
- 2-s2.0-25844472415
- Other Identifier
- 991021895802304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Microbiology