Journal article
Molecular Epidemiology of p53 Protein Mutations in Workers Exposed to Vinyl Chloride
American journal of epidemiology, v 147(3)
01 Feb 1998
PMID: 9482505
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The production of mutations in cellular tumor suppressor genes such as p53 is involved in the development of many human cancers. These mutations result in the expression of mutant forms of the encoded p53 protein which can potentially serve as a biomarker for this carcinogenic process. Workers exposed to vinyl chloride who are at risk for the development of the sentinel neoplasm angiosarcoma of the liver represent a model population for the study of such a mutant p53 biomarker, since vinyl chloride is known to cause specific p53 mutations in persons with angiosarcoma of the liver. To determine the relation between vinyl chloride exposure and this p53 biomarker, the authors examined serum samples collected between 1987 and 1992 from a cohort of 225 French vinyl chloride workers and 111 unexposed controls (matched according to age, sex, race, smoking, and alcohol drinking) for the presence of mutant p53 protein, using an enzyme-linked immunosor-bent assay. Stratification of the exposed workers by quartite of vinyl chloride exposure (in estimated ppm-years) yielded a statistically significant trend of increasing odds ratios for p53 biomarker seropositivity with increasing exposure. These results suggest that this serum biomarker for mutant p53 protein is related to vinyl chloride exposure and may be an early indicator of carcinogenic risk in exposed individuals. Am J Epidemiol 1998; 147: 302–8.
Metrics
Details
- Title
- Molecular Epidemiology of p53 Protein Mutations in Workers Exposed to Vinyl Chloride
- Creators
- Steven J. Smith - Columbia UniversityYongliang Li - Columbia UniversityRonda Whitley - Columbia UniversityMarie-Jeanne Marion - InsermSteven Partilo - Columbia UniversityWalter P. Carney - Oncogene ScienceCambridge, MAPaul W. Brandt-Rauf - Columbia University
- Publication Details
- American journal of epidemiology, v 147(3)
- Publisher
- Oxford University Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems; Drexel University
- Web of Science ID
- WOS:000072011400016
- Scopus ID
- 2-s2.0-0032007332
- Other Identifier
- 991019323783404721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Public, Environmental & Occupational Health