Journal article
Molecular characterization of multidrug-resistant Shigella species isolated from epidemic and endemic cases of shigellosis in India
Journal of medical microbiology, v 57(Pt 7), pp 856-863
01 Jul 2008
PMID: 18566144
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Shigella species represent one of the growing numbers of antimicrobial-resistant bacteria in developing countries. Fluoroquinolone-resistant strains of Shigella dysenteriae type 1 and Shigella flexneri type 2a emerged in India during 2002 and 2003, respectively. Sixty strains of Shigella from different parts of India were analysed for antimicrobial susceptibility, the presence of the qnr plasmid, mutations in the quinolone resistance determining regions (QRDRs), fluoroquinolone accumulation, and the presence of other genes encoding resistance to various antimicrobials. Fluoroquinolone-resistant strains had mutations in gyrA and parC genes and had an active efflux system. They were also resistant to several other antimicrobials but were susceptible to azithromycin and ceftriaxone. The majority of the strains harboured genes encoding resistance to ampicillin (97 %), tetracycline (95 %), streptomycin (95 %) and chloramphenicol (94 %). PFGE analysis revealed clonality among strains of S. dysenteriae types 1 and 5, S. flexneri type 2a and Shigella boydii type 12.
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Details
- Title
- Molecular characterization of multidrug-resistant Shigella species isolated from epidemic and endemic cases of shigellosis in India
- Creators
- Gururaja Perumal Pazhani - National Institute of Cholera and Enteric DiseasesSwapan Kumar Niyogi - National Institute of Cholera and Enteric DiseasesAnil Kumar Singh - Bose InstituteBhaswati Sen - National Institute of Cholera and Enteric DiseasesNeelam Taneja - Post Graduate Institute of Medical Education and ResearchManikuntala Kundu - Bose InstituteShinji Yamasaki - Osaka Prefecture UniversityThandavarayan Ramamurthy - National Institute of Cholera and Enteric Diseases
- Publication Details
- Journal of medical microbiology, v 57(Pt 7), pp 856-863
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology; College of Medicine
- Web of Science ID
- WOS:000257520100010
- Scopus ID
- 2-s2.0-48949092646
- Other Identifier
- 991021448043504721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Microbiology