Journal article
Molecular concentration of deoxyHb in human prefrontal cortex predicts the emergence and suppression of consciousness
NeuroImage (Orlando, Fla.), v 85, pp 616-625
15 Jan 2014
PMID: 23872157
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This is the first study to use fNIRS to explore anaesthetic depth and awakening during surgery with general anaesthesia. A 16 channel continuous wave (CW) functional near-infrared system (fNIRS) was used to monitor PFC activity. These outcomes were compared to BIS measures. The results indicate that deoxyHb concentration in the PFC varies during the suppression and emergence of consciousness. During suppression, deoxyHb levels increase, signalling the deactivation of the PFC, while during emergence, deoxyHb concentration drops, initiating PFC activation and the recovery of consciousness. Furthermore, BIS and deoxyHb concentrations in the PFC display a high negative correlation throughout the different anaesthetic phases. These findings suggest that deoxyHb could be a reliable marker for monitoring anaesthetic depth, and that the PFC intervenes in the suppression and emergence of consciousness.
•First study to use fNIRS to monitor general anaesthesia during a surgical procedure.•DeoxyHb can predict the different anaesthetic states during general anaesthesia.•DeoxyHb level in the PFC is a reliable marker for anaesthetic depth.•PFC is associated with the emergence and suppression of consciousness.
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Details
- Title
- Molecular concentration of deoxyHb in human prefrontal cortex predicts the emergence and suppression of consciousness
- Creators
- Umberto Leon-Dominguez - Autonomous University of MadridMeltem Izzetoglu - Drexel UniversityJose Leon-Carrion - University of SevilleIgnacio Solís-Marcos - University of SevilleFrancisco Jose Garcia-Torrado - Hospital Universitario Virgen del RocíoAna Forastero-Rodríguez - Hospital Universitario Virgen del RocíoPatricia Mellado-Miras - Hospital Universitario Virgen del RocíoDiego Villegas-Duque - Hospital Universitario Virgen del RocíoJuan Luis Lopez-Romero - Hospital Universitario Virgen del RocíoBanu Onaral - Drexel UniversityKurtulus Izzetoglu - Drexel University
- Publication Details
- NeuroImage (Orlando, Fla.), v 85, pp 616-625
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000328869700058
- Scopus ID
- 2-s2.0-84889639046
- Other Identifier
- 991019168208904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neuroimaging
- Neurosciences
- Radiology, Nuclear Medicine & Medical Imaging