Journal article
Molecular inference of sources and spreading patterns of Plasmodium falciparum malaria parasites in internally displaced persons settlements in Myanmar–China border area
Infection, genetics and evolution, v 33, pp 189-196
01 Jul 2015
PMID: 25952567
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
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•Falciparum in the IDP showed reduced genetic diversity over the past three years.•Genetic diversity of P. falciparum was lower in the IDP than in local community.•Falciparum infections detected in China were introduced from Myanmar IDP settlements.•Malaria spreads locally in Myanmar and across international border via human movement.
In Myanmar, civil unrest and establishment of internally displaced persons (IDP) settlement along the Myanmar–China border have impacted malaria transmission. The growing IDP populations raise deep concerns about health impact on local communities. Microsatellite markers were used to examine the source and spreading patterns of Plasmodium falciparum between IDP settlement and surrounding villages in Myanmar along the China border. Genotypic structure of P. falciparum was compared over the past three years from the same area and the demographic history was inferred to determine the source of recent infections. In addition, we examined if border migration is a factor of P. falciparum infections in China by determining gene flow patterns across borders. Compared to local community, the IDP samples showed a reduced and consistently lower genetic diversity over the past three years. A strong signature of genetic bottleneck was detected in the IDP samples. P. falciparum infections from the border regions in China were genetically similar to Myanmar and parasite gene flow was not constrained by geographical distance. Reduced genetic diversity of P. falciparum suggested intense malaria control within the IDP settlement. Human movement was a key factor to the spread of malaria both locally in Myanmar and across the international border.
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Details
- Title
- Molecular inference of sources and spreading patterns of Plasmodium falciparum malaria parasites in internally displaced persons settlements in Myanmar–China border area
- Creators
- Eugenia Lo - University of California, IrvineGuofa Zhou - University of California, IrvineWinny Oo - University of California, IrvineMing-Chieh Lee - University of California, IrvineElisabeth Baum - University of California, IrvinePhilip L. Felgner - University of California, IrvineZhaoqing Yang - Kunming Medical UniversityLiwang Cui - Pennsylvania State UniversityGuiyun Yan - University of California, Irvine
- Publication Details
- Infection, genetics and evolution, v 33, pp 189-196
- Publisher
- Elsevier B.V
- Number of pages
- 8
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000357438300026
- Scopus ID
- 2-s2.0-84928975295
- Other Identifier
- 991022192028104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Infectious Diseases