Journal article
Molecular mechanisms of the preventable causes of cancer in the United States
Genes & development, v 32(13-14), pp 868-902
01 Jul 2018
PMID: 29945886
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Annually, there are 1.6 million new cases of cancer and nearly 600,000 cancer deaths in the United States alone. The public health burden associated with these numbers has motivated enormous research efforts into understanding the root causes of cancer. These efforts have led to the recognition that between 40% and 45% of cancers are associated with preventable risk factors and, importantly, have identified specific molecular mechanisms by which these exposures modify human physiology to induce or promote cancer. The increasingly refined knowledge of these mechanisms, which we summarize here, emphasizes the need for greater efforts toward primary cancer prevention through mitigation of modifiable risk factors. It also suggests exploitable avenues for improved secondary prevention (which includes the development of therapeutics designed for cancer interception and enhanced techniques for noninvasive screening and early detection) based on detailed knowledge of early neoplastic pathobiology. Such efforts would complement the current emphasis on the development of therapeutic approaches to treat established cancers and are likely to result in far greater gains in reducing morbidity and mortality.
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Details
- Title
- Molecular mechanisms of the preventable causes of cancer in the United States
- Creators
- Erica A. Golemis - Fox Chase Cancer CenterPaul Scheet - The University of Texas MD Anderson Cancer CenterTim N. Beck - Fox Chase Cancer CenterEward M. Scolnick - Broad InstituteDavid J. Hunter - University of OxfordErnest Hawk - The University of Texas MD Anderson Cancer CenterNancy Hopkins - Massachusetts Institute of Technology
- Publication Details
- Genes & development, v 32(13-14), pp 868-902
- Publisher
- Cold Spring Harbor Lab Press, Publications Dept
- Number of pages
- 35
- Grant note
- P30CA006927; P30CA016672; F30CA180607 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) Boone Pickens Distinguished Chair for Early Prevention of Cancer R01DK108195 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) 5P30 CA006927; 5P30 CA016672-37 / National Cancer Institute Cancer Center Support grants
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000437221000002
- Scopus ID
- 2-s2.0-85049512928
- Other Identifier
- 991019318931604721
UN Sustainable Development Goals (SDGs)
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology
- Developmental Biology
- Genetics & Heredity