Journal article
Monoclonal antibodies with cytotoxic reactivities against human gliomas
Journal of neurosurgery, v 71(6), pp 892-897
Dec 1989
PMID: 2585082
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
✓ Monoclonal antibodies (MAb's) reactive with human malignant glioma cells were derived from mice inoculated with cells from fresh glioma tissue. Seven MAb's were selected for study based on their high-level binding in immunoperoxidase and immunofluorescence assay to most of the glioma tissues derived from various patients and based on the absence of binding to normal bone marrow cells. Four of the seven MAb's did not bind to any of the four normal brain tissues tested, whereas three MAb's bound to one or two of these tissues. Two MAb's bound to the surfaces of cultured glioma cells in radioimmunoassay. One of these MAb's (AS-AY1, immunoglobulin (Ig)G
1
) lysed cultured glioma cells with human lymphocytes or murine macrophages as effector cells; the other MAb (AS-AY2, IgM) was reactive in complement-dependent cytotoxicity assay. These two MAb's therefore seem especially promising reagents in approaches to immunotherapy of human malignant glioma.
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Details
- Title
- Monoclonal antibodies with cytotoxic reactivities against human gliomas
- Creators
- Anil Nanda - Hahnemann University HospitalBoleslaw Liwnicz - The Wistar InstituteBarbara F. Atkinson - The Wistar InstituteBen-Ami Sela - The Wistar InstituteHiroshi Takahashi - The Wistar InstitutePaul H. Belser - The Wistar InstitutePerry Black - The Wistar InstituteHilary Koprowski - The Wistar InstituteDorothee Herlyn - The Wistar Institute
- Publication Details
- Journal of neurosurgery, v 71(6), pp 892-897
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:A1989CB50900016
- Scopus ID
- 2-s2.0-0024404894
- Other Identifier
- 991019318924504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Surgery