Journal article
Monoclonal antibody-induced cytokine-release syndrome
Expert review of clinical immunology, v 5(5), pp 499-521
01 Sep 2009
PMID: 20477639
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Monoclonal antibodies (mAbs) are widely used in anti-inflammatory and tumor therapy. Although effective, mAbs can cause a variety of adverse effects. An important toxicity seen with a few mAbs is cytokine-release syndrome (CRS). These mAbs include: alemtuzumab, muromonab-CD3, rituximab, tosituzumab, CP-870,893, LO-CD2a/BTI-322 and TGN1412. By contrast, over 30 mAbs used clinically are not associated with CRS. In this review, the clinical aspects of CRS, the mAbs associated with CRS, the cytokines involved and putative mechanisms mediating cytokine release will be discussed. This will be followed by a discussion of the poor predictive value of studies in animals and the prospects for creating in vitro screens. Finally, approaches to decreasing the probability of CRS, decreasing the severity or treating CRS, should it occur, will be described.
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Details
- Title
- Monoclonal antibody-induced cytokine-release syndrome
- Creators
- Peter J. Bugelski - Drexel UniversityRam Achuthanandam - Toxicology and Investigational Pharmacology, Centocor R&D, Radnor, PA, USA. rachutha@its.jnj.comRenold J. Capocasale - Toxicology and Investigational Pharmacology, Centocor R&D, Radnor, PA, USA. rcapoc@its.jnj.comGeorge Treacy - Toxicology and Investigational Pharmacology and Translational Medicine, Centocor R&D, Radnor, PA, USA. gtreacy@its.jnj.comEsther Bouman-Thio - Translational Medicine, Centocor R&D, Radnor, PA, USA. ethio2@its.jnj.com
- Publication Details
- Expert review of clinical immunology, v 5(5), pp 499-521
- Publisher
- Taylor & Francis
- Number of pages
- 23
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000270802100009
- Scopus ID
- 2-s2.0-73849133113
- Other Identifier
- 991019167841204721
UN Sustainable Development Goals (SDGs)
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Source: SDGs in the Output
InCites Highlights
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Immunology