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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Monocytes Mediate HIV Neuropathogenesis: Mechanisms that Contribute to HIV Associated Neurocognitive Disorders
Current HIV research, v 12(2), pp 85-96
01 Jan 2014
PMID: 24862333
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
HIV infected people are living longer due to the success of combined antiretroviral therapy (cART). However, greater than 40-70% of HIV infected individuals develop HIV associated neurocognitive disorders (HAND) that continues to be a major public health issue. While cART reduces peripheral virus, it does not limit the low level, chronic neuroinflammation that is ongoing during the neuropathogenesis of HIV. Monocyte transmigration across the blood brain barrier (BBB), specifically that of the mature CD14(+)CD16(+) population that is highly susceptible to HIV infection, is critical to the establishment of HAND as these cells bring virus into the brain and mediate the neuroinflammation that persists, even if at low levels, despite antiretroviral therapy. CD14(+)CD16(+) monocytes preferentially migrate into the CNS early during peripheral HIV infection in response to chemotactic signals, including those from CCL2 and CXCL12. Once within the brain, monocytes differentiate into macrophages and elaborate inflammatory mediators. Monocytes/macrophages constitute a viral reservoir within the CNS and these latently infected cells may perpetuate the neuropathogenesis of HIV. This review will discuss mechanisms that mediate transmigration of CD14(+)CD16(+) monocytes across the BBB in the context of HIV infection, the contribution of these cells to the neuropathogenesis of HIV, and potential monocyte/macrophage biomarkers to identify HAND and monitor its progression.
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Details
- Title
- Monocytes Mediate HIV Neuropathogenesis: Mechanisms that Contribute to HIV Associated Neurocognitive Disorders
- Creators
- Dionna W. Williams - Yeshiva UniversityMike Veenstra - Yeshiva UniversityPeter J. Gaskill - Yeshiva UniversitySusan Morgello - Icahn School of Medicine at Mount SinaiTina M. Calderon - Yeshiva UniversityJoan W. Berman - Albert Einstein College of Medicine
- Publication Details
- Current HIV research, v 12(2), pp 85-96
- Publisher
- Bentham Science Publ Ltd
- Number of pages
- 12
- Grant note
- UNCF/Merck Graduate Science Dissertation Fellowship AI-051519 / CFAR U01MH083501 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) K01DA029476 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission MH075679; MH090958; MH080663; MH083501; DA025567; DA029476 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA P30AI051519 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) T32AI070117 / NIAID; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Pharmacology and Physiology; Drexel University
- Web of Science ID
- WOS:000340627600003
- Scopus ID
- 2-s2.0-84905656041
- Other Identifier
- 991020100214904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Infectious Diseases
- Virology