Journal article
Monomer diffusion into polymer domains in sickle hemoglobin
Biophysical journal, v 58(4), pp 1067-1073
Oct 1990
PMID: 2248990
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The gelation of sickle hemoglobin includes the formation of spherulitic arrays of polymers, known as polymer domains, which are an intrinsic result of the polymer formation mechanism. We have observed the diffusion of monomers into domains as they form, which substantially increases the total concentration of hemoglobin within the domain. The maximum total concentration attained is comparable with the pellet concentration of 0.5-0.55 g/cm3 obtained in sedimentation experiments. The half time for this process is approximately 50 s for domains of 25 microns radius, and is approximately independent of temperature. The shape of the diffusion progress curves as well as the deduced diffusion constants, and their weak temperature dependence are consistent with a simple model of hemoglobin monomer diffusion into the domain.
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Details
- Title
- Monomer diffusion into polymer domains in sickle hemoglobin
- Creators
- M R Cho - Department of Physics and Atmospheric Science, Drexel University, Philadelphia, Pennsylvania 19104F A Ferrone
- Publication Details
- Biophysical journal, v 58(4), pp 1067-1073
- Publisher
- Elsevier; United States
- Grant note
- HL28102 / NHLBI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Physics
- Web of Science ID
- WOS:A1990EB68200023
- Scopus ID
- 2-s2.0-0025024712
- Other Identifier
- 991014877881604721
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- Web of Science research areas
- Biophysics