Journal article
Motifs of human high-frequency oscillations structure processing and memory of continuous audiovisual narratives
Science advances, v 11(30), eadv0986
25 Jul 2025
PMID: 40712018
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The discrete events of our narrative experience are organized by the neural substrate that underlies episodic memory. This narrative process is segmented into distinct units by event boundaries, which facilitate a replay process that acts to consolidate each event into a narrative memory. High-frequency oscillations (HFOs) may synchronize neural activity during these processes. We use intracranial recordings from participants viewing and freely recalling a continuous, audiovisual stimulus. We find that hippocampal HFOs increase following event boundaries and hippocampal-cortical coincident HFOs (co-HFOs) occur in cortical regions that underlie event segmentation (inferior parietal, precuneus, lateral occipital, and inferior frontal cortices). Event-specific co-HFO patterns that occur during event viewing reoccur following event boundaries for the subsequent three events and during recall. This is consistent with models that support replay as a mechanism for memory consolidation. Therefore, HFOs may coordinate activity across brain regions that facilitate event segmentation, encode memory of discrete events, and bind representations to assemble memory of a coherent, continuous experience.
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Details
- Title
- Motifs of human high-frequency oscillations structure processing and memory of continuous audiovisual narratives
- Creators
- Akash Mishra (Corresponding Author) - Feinstein Institute for Medical ResearchGelana Tostaeva - Northwell HealthMaximilian Nentwich - Northwell HealthElizabeth Espinal - Drexel UniversityNoah Markowitz - Northwell HealthJalen Winfield - Northwell HealthElisabeth Freund - Northwell HealthSabina Gherman - Northwell HealthMarcin Leszczynski - Jagiellonian UniversityCharles E Schroeder - Nathan Kline Institute for Psychiatric ResearchAshesh D Mehta - Feinstein Institute for Medical ResearchStephan Bickel - Nathan Kline Institute for Psychiatric Research
- Publication Details
- Science advances, v 11(30), eadv0986
- Publisher
- American Association for the Advancement of Science
- Grant note
- F30 MH139332 / NIMH NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:001535436800005
- Scopus ID
- 2-s2.0-105012212098
- Other Identifier
- 991022197319804721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences