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Journal article
Motoneuron firing patterns underlying fast oscillations in phrenic nerve discharge in the rat
Journal of neurophysiology, v 108(8), pp 2134-2143
01 Oct 2012
PMID: 22815408
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Marchenko V, Ghali MG, Rogers RF. Motoneuron firing patterns underlying fast oscillations in phrenic nerve discharge in the rat. J Neurophysiol 108: 2134-2143, 2012. First published July 18, 2012; doi: 10.1152/jn.00292.2012.-Fast oscillations are ubiquitous throughout the mammalian central nervous system and are especially prominent in respiratory motor outputs, including the phrenic nerves (PhNs). Some investigators have argued for an epiphenomenological basis for PhN high-frequency oscillations because phrenic motoneurons (PhMNs) firing at these same frequencies have never been recorded, although their existence has never been tested systematically. Experiments were performed on 18 paralyzed, unanesthetized, decerebrate adult rats in which whole PhN and individual PhMN activity were recorded. A novel method for evaluating unit-nerve time-frequency coherence was applied to PhMN and PhN recordings. PhMNs were classified according to their maximal firing rate as high, medium, and low frequency, corresponding to the analogous bands in PhN spectra. For the first time, we report the existence of PhMNs firing at rates corresponding to high-frequency oscillations during eupneic motor output. The majority of PhMNs fired only during inspiration, but a small subpopulation possessed tonic activity throughout all phases of respiration. Significant time-varying PhMN-PhN coherence was observed for all PhMN classes. High-frequency, early-recruited units had significantly more consistent onset times than low-frequency, early/middle-recruited and medium-frequency, middle/late-recruited PhMNs. High- and medium-frequency PhMNs had significantly more consistent offset times than low-frequency units. This suggests that startup and termination of PhMNs with higher firing rates are more precisely controlled, which may contribute to the greater PhMN-PhN coherence at the beginning and end of inspiration. Our findings provide evidence that near-synchronous discharge of PhMNs firing at high rates may underlie fast oscillations in PhN discharge.
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Details
- Title
- Motoneuron firing patterns underlying fast oscillations in phrenic nerve discharge in the rat
- Creators
- Vitaliy Marchenko - Drexel UniversityMichael G. Z. Ghali - Drexel UniversityRobert F. Rogers - Drexel University
- Publication Details
- Journal of neurophysiology, v 108(8), pp 2134-2143
- Publisher
- Amer Physiological Soc
- Number of pages
- 10
- Grant note
- HL68143 / National Heart, Lung, and Blood Institute Grant; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) R01NS069220 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) R01HL068143 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000310057500005
- Scopus ID
- 2-s2.0-84867712905
- Other Identifier
- 991019312455704721
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- Web of Science research areas
- Neurosciences
- Physiology