Journal article
Mouse models of brain tumors and their applications in preclinical trials
Clinical cancer research, v 12(18), pp 5288-5297
15 Sep 2006
PMID: 17000661
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Primary brain tumors, including gliomas and medulloblastomas, often represent the most devastating and difficult-to-treat tumors, and are thought to arise from glial cells and/or their precursors or the external granule cell layer, respectively. The majority of genetic alterations characteristic of the human brain tumors are thought to occur in genes encoding proteins involved in signal transduction or cell cycle regulation. Accurate recapitulation of these genetic alterations using genetically engineered mouse models allows for in vivo modeling of brain tumors with similar histopathology, etiology, and biology. These mouse models, in turn, increase our understanding of brain tumor initiation, formation, progression, and metastasis, providing an experimental system to discover novel therapeutic targets and test various therapeutic agents.
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Details
- Title
- Mouse models of brain tumors and their applications in preclinical trials
- Creators
- Elena I Fomchenko - Memorial Sloan Kettering Cancer CenterEric C Holland - Memorial Sloan Kettering Cancer Center
- Publication Details
- Clinical cancer research, v 12(18), pp 5288-5297
- Publisher
- American Association for Cancer Research (AACR)
- Grant note
- R01 CA100688 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurology
- Web of Science ID
- WOS:000240714400010
- Scopus ID
- 2-s2.0-33749333727
- Other Identifier
- 991022004957004721
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- Web of Science research areas
- Oncology