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Multi-View Clustering of Microbiome Samples by Robust Similarity Network Fusion and Spectral Clustering
Journal article   Open access

Multi-View Clustering of Microbiome Samples by Robust Similarity Network Fusion and Spectral Clustering

Yong Zhang, Xiaohua Hu and Xingpeng Jiang
IEEE/ACM transactions on computational biology and bioinformatics, v 14(2), pp 264-271
Mar 2017
PMID: 26513798
url
https://doi.org/10.1109/TCBB.2015.2474387View
Published, Version of Record (VoR) Open

Abstract

Computational Biology - methods Algorithms Microbiota - genetics Databases, Protein Humans Cluster Analysis
Microbiome datasets are often comprised of different representations or views which provide complementary information, such as genes, functions, and taxonomic assignments. Integration of multi-view information for clustering microbiome samples could create a comprehensive view of a given microbiome study. Similarity network fusion (SNF) can efficiently integrate similarities built from each view of data into a unique network that represents the full spectrum of the underlying data. Based on this method, we develop a Robust Similarity Network Fusion (RSNF) approach which combines the strength of random forest and the advantage of SNF at data aggregation. The experimental results indicate the strength of the proposed strategy. The method substantially improves the clustering performance significantly comparing to several state-of-the-art methods in several datasets.

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18 citations in Scopus

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Biochemical Research Methods
Computer Science, Interdisciplinary Applications
Mathematics, Interdisciplinary Applications
Statistics & Probability
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