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Journal article
Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits
HGG advances, v 2(1), 100013
14 Jan 2021
PMID: 34734193
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Psychological and social factors are known to influence blood pressure (BP) and risk of hypertension and associated cardiovascular diseases. To identify novel BP loci, we carried out genome-wide association meta-analyses of systolic, diastolic, pulse, and mean arterial BP, taking into account the interaction effects of genetic variants with three psychosocial factors: depressive symptoms, anxiety symptoms, and social support. Analyses were performed using a two-stage design in a sample of up to 128,894 adults from five ancestry groups. In the combined meta-analyses of stages 1 and 2, we identified 59 loci (p value < 5e−8), including nine novel BP loci. The novel associations were observed mostly with pulse pressure, with fewer observed with mean arterial pressure. Five novel loci were identified in African ancestry, and all but one showed patterns of interaction with at least one psychosocial factor. Functional annotation of the novel loci supports a major role for genes implicated in the immune response (PLCL2), synaptic function and neurotransmission (LIN7A and PFIA2), as well as genes previously implicated in neuropsychiatric or stress-related disorders (FSTL5 and CHODL). These findings underscore the importance of considering psychological and social factors in gene discovery for BP, especially in non-European populations.
This genome-wide association study systematically evaluated the joint effect of SNPs and SNP-by-psychosocial factor interactions on BP in a large and diverse sample. Findings of the study underscore the importance of considering psychological and social factors in gene discovery for BP, especially in African ancestry.
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- Title
- Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits
- Creators
- Daokun Sun - The University of Texas Health Science Center at HoustonMelissa A. Richard - The University of Texas Health Science Center at HoustonSolomon K. Musani - University of Mississippi Medical CenterYun Ju Sung - Washington University in St. LouisThomas W. Winkler - University of RegensburgKaren Schwander - Washington University in St. LouisJin Fang Chai - National University of SingaporeXiuqing Guo - Los Angeles Biomedical Research InstituteTuomas O. Kilpeläinen - Icahn School of Medicine at Mount SinaiDina Vojinovic - Erasmus MCHugues Aschard - Harvard UniversityTraci M. Bartz - University of WashingtonLawrence F. Bielak - University of Michigan–Ann ArborMichael R. Brown - The University of Texas Health Science Center at HoustonKumaraswamy Chitrala - National Institutes of HealthFernando P. Hartwig - University of BristolAndrea R.V.R. Horimoto - Universidade de São PauloYongmei Liu - Duke UniversityAlisa K. Manning - Harvard UniversityRaymond Noordam - Leiden University Medical CenterAlbert V. Smith - University of Michigan–Ann ArborSarah E. Harris - University of EdinburghBrigitte Kühnel - Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, GermanyLeo-Pekka Lyytikäinen - University of TampereIlja M. Nolte - University Medical Center GroningenRainer Rauramaa - Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio 70100, FinlandPeter J. van der Most - University Medical Center GroningenRujia Wang - University Medical Center GroningenErin B. Ware - University of Michigan–Ann ArborStefan Weiss - Greifswald University HospitalWanqing Wen - Vanderbilt UniversityLisa R. Yanek - Johns Hopkins MedicineDan E. Arking - Johns Hopkins MedicineDonna K. Arnett - University of KentuckyAna Barac - MedStar Heart and Vascular Institute, Washington, DC 20010, USAEric Boerwinkle - Baylor College of MedicineUlrich Broeckel - Medical College of WisconsinAravinda Chakravarti - New York UniversityYii-Der Ida Chen - Los Angeles Biomedical Research InstituteL. Adrienne Cupples - Boston UniversityMartha L. Davigulus - University of Illinois at ChicagoLisa de las Fuentes - Washington University in St. LouisRenée de Mutsert - Leiden University Medical CenterPaul S. de Vries - The University of Texas Health Science Center at HoustonJoseph A.C. Delaney - University of ManitobaAna V. Diez Roux - Drexel UniversityMarcus Dörr - Greifswald University HospitalJessica D. Faul - University of Michigan–Ann ArborAmanda M. Fretts - University of WashingtonLinda C. Gallo - Department of Psychology, San Diego State University, San Diego, CA 92182, USAHans Jörgen Grabe - Greifswald University HospitalC. Charles Gu - Washington University in St. LouisTamara B. Harris - National Institutes of HealthCatharina C.A. Hartman - Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, Groningen 9713 GZ, the NetherlandsSami Heikkinen - University of Eastern FinlandM. Arfan Ikram - Erasmus MCCarmen Isasi - Albert Einstein College of MedicineW. Craig Johnson - University of WashingtonJost Bruno Jonas - Capital Medical UniversityRobert C. Kaplan - Albert Einstein College of MedicinePirjo Komulainen - Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio 70100, FinlandJose E. Krieger - Universidade de São PauloDaniel Levy - Boston UniversityJianjun Liu - Agency for Science, Technology and ResearchKurt Lohman - Duke UniversityAnnemarie I. Luik - Erasmus MCLisa W. Martin - George Washington UniversityThomas Meitinger - Technical University of MunichYuri Milaneschi - Amsterdam UMC Location VUmcJeff R. O’Connell - Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USAWalter R. Palmas - Columbia University Medical CenterAnnette Peters - Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, GermanyPatricia A. Peyser - University of Michigan–Ann ArborLaura Pulkki-Råback - University of HelsinkiLeslie J. Raffel - University of California, IrvineAlex P. Reiner - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USAKenneth Rice - University of WashingtonJennifer G. Robinson - Departments of Epidemiology and Medicine, University of Iowa, Iowa City, IA 52242, USAFrits R. Rosendaal - Leiden University Medical CenterCarsten Oliver Schmidt - Greifswald University HospitalPamela J. Schreiner - University of MinnesotaLars Schwettmann - Institute of Health Economics and Health Care Management, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, GermanyJames M. Shikany - University of Alabama at BirminghamXiao-ou Shu - Vanderbilt UniversityStephen Sidney - Kaiser PermanenteMario Sims - University of Mississippi Medical CenterJennifer A. Smith - University of Michigan–Ann ArborNona Sotoodehnia - University of WashingtonKonstantin Strauch - Ludwig-Maximilians-Universität MünchenE. Shyong Tai - National University of SingaporeKent D. Taylor - Los Angeles Biomedical Research InstituteAndré G. Uitterlinden - Erasmus MCCornelia M. van Duijn - University of OxfordMelanie Waldenberger - Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, GermanyHwee-Lin Wee - National University of SingaporeWen-Bin Wei - Capital Medical UniversityGregory Wilson - Jackson State UniversityDeng Xuan - Boston UniversityJie Yao - Los Angeles Biomedical Research InstituteDonglin Zeng - University of North Carolina at Chapel HillWei Zhao - University of Michigan–Ann ArborXiaofeng Zhu - Case Western Reserve UniversityAlan B. Zonderman - National Institutes of HealthDiane M. Becker - Johns Hopkins MedicineIan J. Deary - University of EdinburghChristian Gieger - Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, GermanyTimo A. Lakka - University of Eastern FinlandTerho Lehtimäki - University of TampereKari E. North - University of North Carolina at Chapel HillAlbertine J. Oldehinkel - University Medical Center GroningenBrenda W.J.H. Penninx - Amsterdam UMC Location VUmcHarold Snieder - University Medical Center GroningenYa-Xing Wang - Capital Medical UniversityDavid R. Weir - University of Michigan–Ann ArborWei Zheng - Vanderbilt UniversityMichele K. Evans - National Institutes of HealthW. James Gauderman - University of Southern CaliforniaVilmundur Gudnason - University of IcelandBernardo L. Horta - Universidade Federal de PelotasChing-Ti Liu - Boston UniversityDennis O. Mook-Kanamori - Leiden University Medical CenterAlanna C. Morrison - The University of Texas Health Science Center at HoustonAlexandre C. Pereira - Universidade de São PauloBruce M. Psaty - University of WashingtonNajaf Amin - Erasmus MCErvin R. Fox - University of Mississippi Medical CenterCharles Kooperberg - Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South AfricaXueling Sim - National University of SingaporeLaura Bierut - Washington University in St. LouisJerome I. Rotter - Los Angeles Biomedical Research InstituteSharon L.R. Kardia - University of Michigan–Ann ArborNora Franceschini - University of North Carolina at Chapel HillDabeeru C. Rao - Washington University in St. LouisMyriam Fornage - The University of Texas Health Science Center at HoustonLifelines Cohort Study
- Publication Details
- HGG advances, v 2(1), 100013
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Urban Health Collaborative
- Web of Science ID
- WOS:000787676000001
- Scopus ID
- 2-s2.0-85119177602
- Other Identifier
- 991019168907004721
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- Domestic collaboration
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- Web of Science research areas
- Genetics & Heredity