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Journal article
Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients
Cell reports. Medicine, 101079
23 May 2023
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The IMPACC cohort, composed of >1,000 hospitalized COVID-19 participants, contains five illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1-3) to more severe disease course (TG4) and death (TG5). Here, we report deep immunophenotyping, profiling of >15,000 longitudinal blood and nasal samples from 540 participants of the IMPACC cohort, using 14 distinct assays. These unbiased analyses identify cellular and molecular signatures present within 72 hours of hospital admission that distinguish moderate from severe and fatal COVID-19 disease. Importantly, cellular and molecular states also distinguish participants with more severe disease that recover or stabilize within 28 days from those that progress to fatal outcomes (TG4 vs. TG5). Furthermore, our longitudinal design reveals that these biologic states display distinct temporal patterns associated with clinical outcomes. Characterizing host immune responses in relation to heterogeneity in disease course may inform clinical prognosis and opportunities for intervention.
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•Distinct baseline and temporal patterns are associated with the clinical course.•Persistent viral levels, despite high antibody titers, are associated with severity.•Severity is linked to reduced cytotoxic NK cells, increased inflammation and thrombosis.•Myocardial damage markers distinguish critical patients who recover from those who die.
Diray-Arce et al conduct deep immunophenotyping of acute COVID-19 infection using more than 15,000 longitudinal samples from 540 hospitalized patients in the IMPACC cohort. The study comprehensively defines baseline and longitudinal immunologic states that are associated with mild to fatal disease trajectory groups.
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- Title
- Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients
- Creators
- Joann Diray-Arce - Boston Children's HospitalSlim Fourati - Emory and Henry CollegeNaresh Doni Jayavelu - University of WashingtonRavi Patel - University of California, San FranciscoCole Maguire - University of Texas, Austin, TX 78712, USAAna C. Chang - Boston Children's HospitalRavi Dandekar - University of California, San FranciscoJingjing Qi - Icahn School of Medicine at Mount SinaiBrian Lee - Icahn School of Medicine at Mount SinaiPatrick van Zalm - Boston Children's HospitalAndrew Schroeder - University of California, San FranciscoErnie Chen - Yale School of MedicineAnna Konstorum - Yale School of MedicineAnderson Brito - Yale School of Public Health, New Haven, CT 06510, USAJeremy P. Gygi - Yale School of MedicineAlvin Kho - Boston Children's HospitalJing Chen - Boston Children's HospitalShrikant Pawar - Yale School of MedicineAna Silvia Gonzalez-Reiche - Icahn School of Medicine at Mount SinaiAnnmarie Hoch - Boston Children's HospitalCarly E. Milliren - Boston Children's HospitalJames A. Overton - Knocean Inc. Toronto, ON M6P 2T3, CanadaKerstin Westendorf - La Jolla Institute for Immunology, La Jolla, CA 92037, USACharles B. Cairns - Drexel UniversityNadine Rouphael - Emory and Henry CollegeSteven Bosinger - Emory and Henry CollegeSeunghee Kim-Schulze - Icahn School of Medicine at Mount SinaiFlorian Krammer - Icahn School of Medicine at Mount SinaiLindsey Rosen - National Institute of Allergy and Infectious DiseasesNathan Grubaugh - Yale School of Public Health, New Haven, CT 06510, USAHarm van Bakel - Icahn School of Medicine at Mount SinaiMichael Wilson - University of California, San FranciscoJayant Rajan - University of California, San FranciscoHanno Steen - Boston Children's HospitalWalter Eckalbar - University of California, San FranciscoChris Cotsapas - Yale School of MedicineCharles R. Langelier - University of California, San FranciscoOfer Levy - Boston Children's HospitalMatthew C. Altman - University of WashingtonHolden Maecker - National Institute of Allergy and Infectious DiseasesRuth R. Montgomery - Yale School of MedicineElias K. Haddad - Drexel UniversityRafick P. Sekaly - Emory and Henry CollegeDenise Esserman - Yale School of Public Health, New Haven, CT 06510, USAAl Ozonoff - Boston Children's HospitalPatrice M. Becker - National Institute of Allergy and Infectious DiseasesAlison D. Augustine - National Institute of Allergy and Infectious DiseasesLeying Guan - Yale School of Public Health, New Haven, CT 06510, USABjoern Peters - La Jolla Institute for Immunology, La Jolla, CA 92037, USASteven H. Kleinstein - Yale School of MedicineIMPACC Network
- Publication Details
- Cell reports. Medicine, 101079
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Infectious Diseases (and HIV Medicine)
- Web of Science ID
- WOS:001036234500001
- Scopus ID
- 2-s2.0-85162133285
- Other Identifier
- 991020547835704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology
- Medicine, Research & Experimental