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Multi-scale hierarchical scaffolds with aligned micro-fibers for promoting cell alignment
Journal article   Peer reviewed

Multi-scale hierarchical scaffolds with aligned micro-fibers for promoting cell alignment

Chengjin Wang, Yuanyuan Xu, Jingjing Xia, Zhenzhen Zhou, Yongcong Fang, Lei Zhang and Wei Sun
Biomedical materials (Bristol), v 16(4), pp 045047/1-045047/13
28 Jun 2021
DOI: https://doi.org/10.1088/1748-605X/ac0a90
PMID: 34116518
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Animals Biocompatible Materials - chemistry Biocompatible Materials - pharmacology Cell Adhesion - drug effects Cell Adhesion - physiology Cell Line Cell Proliferation - drug effects Cell Proliferation - physiology Electrochemical Techniques Human Umbilical Vein Endothelial Cells - cytology Humans Mice Nanofibers - chemistry Printing, Three-Dimensional Tissue Engineering Tissue Scaffolds - chemistry
Cell alignment plays an essential role in cytoskeleton reorganization, extracellular matrix remodeling, and biomechanical properties regulation of tissues such as vascular tissues, cardiac muscles, and tendons. Based on the natural-oriented features of cells in native tissues, various biomimetic scaffolds have been reported with the introduction of well-arranged ultrafine fibers to induce cell alignment. However, it is still a challenge to fabricate scaffolds with suitable mechanical properties, biomimetic microenvironment, and ability to promote cell alignment. In this paper, we propose an integrated 3D printing system to fabricate multi-scale hierarchical scaffolds combined with meso-, micro-, and nano-fibrous filaments, in which the meso-, micro-, and nano-fibers fabricated via fused deposition modeling, melt electrospining writing, and solution electrospining can provide structural support, promote cell alignment, and create a biomimetic microenvironment to facilitate cell function, respectively. The plasma surface modification was performed improve the surface wettability of the scaffolds by measuring the contact angle. The obtained biological results validate the ability of multi-scale hierarchical scaffolds to enhance cell adhesion and proliferation, and promote cell alignment with the guidance of the aligned microfibers produced via melt electrospining writing in hierarchical scaffolds.

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20 citations in Web of Science
21 citations in Scopus

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UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Engineering, Biomedical
Materials Science, Biomaterials
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