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Multi-targeted molecular therapeutic approach in aggressive neuroblastoma: the effect of Focal Adhesion Kinase-Src-Paxillin system
Journal article   Peer reviewed

Multi-targeted molecular therapeutic approach in aggressive neuroblastoma: the effect of Focal Adhesion Kinase-Src-Paxillin system

Panagiotis Kratimenos, Ioannis Koutroulis, Dante Marconi, Vasiliki Syriopoulou, Maria Delivoria-Papadopoulos, George P Chrousos and Stamatios Theocharis
Expert opinion on therapeutic targets, v 18(12), pp 1395-1406
Dec 2014
DOI: https://doi.org/10.1517/14728222.2014.952280
PMID: 25189706
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - metabolism Drug Resistance, Multiple - drug effects Drug Resistance, Multiple - physiology Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - physiology Focal Adhesion Kinase 1 - antagonists & inhibitors Focal Adhesion Kinase 1 - metabolism Humans Molecular Targeted Therapy - methods Neuroblastoma - drug therapy Neuroblastoma - metabolism Paxillin - antagonists & inhibitors Paxillin - metabolism src-Family Kinases - antagonists & inhibitors src-Family Kinases - metabolism
Nonreceptor tyrosine kinases play key roles in the integrin system. Located at the focal adhesions, they consist of large protein complexes through which the cytoskeleton connects to the extracellular matrix. The focal adhesion kinase (FAK)-Src-paxillin complex, a major mediator of the integrin pathway, contributes to cell migration and motility. Its overexpression is increased in children with advanced neuroblastoma (NB), one of the most common malignancies of childhood, with poor survival. We review the most recent data on FAK-Src-paxillin and their implications in NB, the molecular structure and the regulatory mechanisms of each molecule and their interactions and up-to-date information on their use as the newest biomarkers and their potential use as therapeutic targets in NB. Based on the current literature, we hypothesize that combined and concurrent inhibition of the FAK-Src-Paxillin system may result in significant tumor suppression and prevention or delay of metastasis.

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31 citations in Web of Science
30 citations in Scopus

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Web of Science research areas
Pharmacology & Pharmacy
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